Characterising activity and diet compositions for dementia prevention: protocol for the ACTIVate prospective longitudinal cohort study

被引：7

作者：

Smith, Ashleigh E. ^{[1
]}

Wade, Alexandra T. ^{[1
]}

Olds, Timothy ^{[1
]}

Dumuid, Dorothea ^{[1
]}

Breakspear, Michael J. ^{[2
,3
]}

Laver, Kate ^{[4
]}

Goldsworthy, Mitchell R. ^{[5
,6
]}

Ridding, Michael C. ^{[7
]}

Fabiani, Monica ^{[8
,9
]}

Dorrian, Jillian ^{[10
]}

Hunter, Montana ^{[11
]}

Paton, Bryan ^{[3
]}

Abdolhoseini, Mahmoud ^{[11
]}

Aziz, Fayeem ^{[11
]}

Mellow, Maddison L. ^{[1
]}

Collins, Clare ^{[12
,13
]}

Murphy, Karen J. ^{[14
]}

Gratton, Gabriele ^{[8
,9
]}

Keage, Hannah ^{[10
]}

Smith, Ross T. ^{[15
]}

Karayanidis, Frini ^{[11
]}

机构：

[1] Univ South Australia, Allied Hlth & Human Performance, Alliance Res Exercise Nutr & Act ARENA, Adelaide, SA, Australia

[2] Univ Newcastle, Coll Hlth Med & Wellbeing, Sch Med & Publ Hlth, Callaghan, NSW, Australia

[3] Univ Newcastle, Coll Engn Sci & Environm, Sch Psychol Sci, Callaghan, NSW, Australia

[4] Flinders Univ S Australia, Flinders Hlth & Med Res Inst, Adelaide, SA, Australia

[5] Univ Adelaide, Adelaide Med Sch, Lifespan Human Neurophysiol Grp, Adelaide, SA, Australia

[6] South Australian Hlth & Med Res Inst Ltd, Hopwood Ctr Neurobiol, Lifelong Hlth Theme, Adelaide, SA, Australia

[7] Univ South Australia, Allied Hlth & Human Performance, Adelaide, SA, Australia

[8] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL USA

[9] Univ Illinois, Psychol Dept, Urbana, IL USA

[10] Univ South Australia, Justice & Soc, Behav Brain & Body Res Ctr, Adelaide, SA, Australia

[11] Univ Newcastle, Coll Engn Sci & Environm, Sch Psychol Sci, Funct Neuroimaging Lab, Callaghan, NSW, Australia

[12] Univ Newcastle, Fac Hlth & Med, Prior Res Ctr Phys Act & Nutr, Callaghan, NSW, Australia

[13] Univ Newcastle, Fac Hlth & Med, Sch Hlth Sci, Callaghan, NSW, Australia

[14] Univ South Australia, Clin & Hlth Sci, Alliance Res Exercise Nutr & Act ARENA, Adelaide, SA, Australia

[15] Univ South Australia, Wearable Comp Lab, Adelaide, SA, Australia

来源：

BMJ OPEN | 2022年 / 12卷 / 01期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会; 澳大利亚研究理事会;

关键词：

dementia; nutrition & dietetics; neurophysiology; public health; FOOD FREQUENCY QUESTIONNAIRE; AGE-RELATED DECLINE; COGNITIVE DECLINE; ALZHEIMERS-DISEASE; OPTICAL MEASURES; VALIDATION; INSTRUMENT; MEMORY; RISK; SUPPLEMENTATION;

D O I：

10.1136/bmjopen-2020-047888

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction Approximately 40% of late-life dementia may be prevented by addressing modifiable risk factors, including physical activity and diet. Yet, it is currently unknown how multiple lifestyle factors interact to influence cognition. The ACTIVate Study aims to (1) explore associations between 24-hour time-use and diet compositions with changes in cognition and brain function; and (2) identify duration of time-use behaviours and the dietary compositions to optimise cognition and brain function. Methods and analysis This 3-year prospective longitudinal cohort study will recruit 448 adults aged 60-70 years across Adelaide and Newcastle, Australia. Time-use data will be collected through wrist-worn activity monitors and the Multimedia Activity Recall for Children and Adults. Dietary intake will be assessed using the Australian Eating Survey food frequency questionnaire. The primary outcome will be cognitive function, assessed using the Addenbrooke's Cognitive Examination-III. Secondary outcomes include structural and functional brain measures using MRI, cerebral arterial pulse measured with diffuse optical tomography, neuroplasticity using simultaneous transcranial magnetic stimulation and electroencephalography, and electrophysiological markers of cognitive control using event-related potential and time frequency analyses. Compositional data analysis, testing for interactions between time point and compositions, will assess longitudinal associations between dependent (cognition, brain function) and independent (time-use and diet compositions) variables. Conclusions The ACTIVate Study will be the first to examine associations between time-use and diet compositions, cognition and brain function. Our findings will inform new avenues for multidomain interventions that may more effectively account for the co-dependence between activity and diet behaviours for dementia prevention. Ethics and dissemination Ethics approval has been obtained from the University of South Australia's Human Research Ethics committee (202639). Findings will be disseminated through peer-reviewed manuscripts, conference presentations, targeted media releases and community engagement events.

引用

页数：12

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