Impact of luminal density on plaque classification by CT coronary angiography

被引:46
作者
Dalager, Maiken Glud [1 ]
Bottcher, Morten [1 ]
Andersen, Gratien [2 ]
Thygesen, Jesper [3 ]
Pedersen, Erik Morre [4 ]
Dejbjerg, Lone [5 ]
Gotzsche, Ole [6 ]
Botker, Hans Erik [1 ]
机构
[1] Aarhus Univ Hosp, Dept Cardiol, DK-8200 Aarhus N, Denmark
[2] Aarhus Univ Hosp, Dept Radiol, DK-8200 Aarhus N, Denmark
[3] Aarhus Univ Hosp, Dept Biomed Engn, DK-8200 Aarhus N, Denmark
[4] Aarhus Sygehus, Dept Radiol, Aarhus Univ Hosp, DK-8000 Aarhus C, Denmark
[5] Silkeborg Hosp, Dept Cardiol, DK-8600 Silkeborg, Denmark
[6] Aarhus Sygehus, Dept Cardiol, Aarhus Univ Hosp, DK-8000 Aarhus C, Denmark
关键词
Atherosclerosis; Cardiac CT; Coronary artery disease; Computed tomography; Intravascular ultrasound; Ischemia; MULTISLICE COMPUTED-TOMOGRAPHY; ATHEROSCLEROTIC CAROTID PLAQUE; RADIOFREQUENCY DATA-ANALYSIS; EX-VIVO MODEL; HISTOPATHOLOGICAL CORRELATION; NONINVASIVE CHARACTERIZATION; IN-VITRO; ROW CT; ARTERIES; ATTENUATION;
D O I
10.1007/s10554-010-9695-z
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Non-invasive coronary CT angiography (CCTA) has the potential to characterize the composition of non-calcified coronary plaques. CT-density values characterized by Hounsfield Units (HU) may classify non-calcified plaques as fibrous or lipid-rich, but the luminal density caused by the applied contrast material influences HU in the plaques in vitro. The influence of luminal density on HU in non-calcified plaques in vivo is unknown. Hence the purpose of this study was to test whether plaque characterization by CCTA in vivo depends on luminal density. Two CCTA-scans using two different contrast protocols were obtained from 14 male patients with coronary artery disease. The two contrast protocols applied resulted in high and low luminal density. Eleven non- calcified and 13 calcified plaques were identified and confirmed by intravascular ultrasound. Luminal attenuation differed with the two contrast protocols; 326[284;367] vs. 118[103;134] HU (P < 0.00001). In non-calcified plaques mean HU-values was lower 48[28;69] vs. 11[-4;25] HU (P = 0.004) with the low density protocol. As a consequence three out of eleven non-calcified plaques (27%) were reclassified from fibrous (high) to lipid rich (low). For calcified plaques a less pronounced but still significant difference in HU-values was found with the low luminal density. 770[622;919] vs. 675[496;855] HU (P = 0.02). Conclusion: Non-calcified plaques can be identified and classified by CCTA. However, the luminal density affects the absolute HU of both non-calcified and calcified plaques. Characterization and classification of non-calcified plaques by absolute CT values therefore requires standardization of contrast protocols.
引用
收藏
页码:593 / 600
页数:8
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