Biomolecular Emission by Swift Heavy Ion Bombardment

被引：0

作者：

Wakamatsu, Yoshinobu ^{[1
]}

Yamada, Hideaki ^{[1
]}

Ninomiya, Satoshi ^{[2
,4
]}

Jones, Brian N. ^{[5
]}

Seki, Toshio ^{[1
,4
]}

Aoki, Takaaki ^{[3
,4
]}

Webb, Roger ^{[5
]}

Matsuo, Jiro ^{[2
,4
]}

机构：

[1] Kyoto Univ, Dept Nucl Engn, Sakyo Ku, Kyoto 6068501, Japan

[2] Kyoto Univ, Quantum Sci & Engn Ctr, Kyoto 6110011, Japan

[3] Kyoto Univ, Dept Elect Sci & Engn, Kyoto 6158510, Japan

[4] Japan Sci & Technol Agcy, Kyoto 1020075, Japan

[5] Univ Surrey, Ion Beam Ctr, Surrey GU2 7XH, England

来源：

ION IMPLANTATION TECHNOLOGY 2010 | 2010年 / 1321卷

基金：

日本科学技术振兴机构;

关键词：

SIMS; secondary ion emission; swift heavy ion; electronic sputtering; biomolecules; MASS-SPECTROMETRY; TOF-SIMS; TISSUE;

D O I：

暂无

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Secondary Ion Mass spectrometry (SIMS) has been generally used in the field of material sciences. In recent years, it has also been applied for molecular imaging of biological samples. Nevertheless, molecular ions derived from the large molecules (more than 1 kDa) were detected with very low sensitivity. Plasma desorption mass spectrometry (PDMS) is known as mass spectrometry for large organic molecule. In PDMS, fission fragments bombard samples and the impact induces molecular ionization by electronic excitation. Large organic molecules are detected by using swift heavy ions in SIMS. In this work, 6 MeV Cu4+ we irradiated angiotensin II, a class of peptides. The intact molecular ions generated by swift heavy ion irradiation were analyzed by time-of-flight (TOF) measurement. The yields are compared with some other probe ions, bismuth or flurane. Swift heavy ion bombardment ionized large organic molecules more effectively than other probes. Therefore, high energy ion can be applied in high resolution molecular imaging.

引用

页码：233 / +

页数：2

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