SYNTHESIS OF 3-[4-(6-BROMO-2-OXO-2H-CHROMEN-3-YL)-1,3-THIAZOL-2-YL]-2-(SUBSTITUTED PHENYL) 1,3-THIAZOLIDIN-4-ONES AND THEIR BIOLOGICAL ACTIVITY

被引：0

作者：

Joshi, Aakanksha ^{[1
]}

Narayanaswamy, Venugopala Katharigatta ^{[2
]}

Rao, Gopal Krishna ^{[1
]}

Devi, Kalpana ^{[1
]}

Pathak, Arun ^{[1
]}

机构：

[1] Al Ameen Coll Pharm, Dept Pharmaceut Chem, Bangalore 560027, Karnataka, India

[2] Univ Kwazulu Natal, Sch Chem, ZA-4041 Durban, South Africa

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2011年 / 20卷 / 03期

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D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 3-[4-(6-bromo-2-oxo-2H-chromen-3-yl) -1,3-thiazol-2-yl]-2-(substituted phenyl) 1,3-thiazolidin-4-ones (4a-h) were synthesized by reacting substituted Schiff bases of aminothiazolyl bromocoumarin with thioglycollic acid in dioxan. The title compounds have been characterized by IR, (1)H NMR, CHN and Mass spectral data. The synthesized compounds were evaluated for their qualitative antibacterial and in-vitro antioxidant activity by agar diffusion and DPPH* methods, respectively. In general, the title compounds have shown mild to moderate antibacterial and antioxidant activity.

引用

页码：295 / 296

页数：2