Role of ergosterol in growth inhibition of Saccharomyces cerevisiae by syringomycin E

被引：14

作者：

Wangspa, R ^{[1
]}

Takemoto, JY ^{[1
]}

机构：

[1] Utah State Univ, Dept Biol, Logan, UT 84322 USA

来源：

FEMS MICROBIOLOGY LETTERS | 1998年 / 167卷 / 02期

关键词：

syringomycin E; ergosterol; Saccharomyces cerevisiae;

D O I：

10.1111/j.1574-6968.1998.tb13231.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The antifungal activity of the lipodepsipeptide syringomycin E from Pseudomonas syringae pv. syringae is modulated by sterols. To study the requirement of the predominant fungal sterol, ergosterol, in syringomycin E action, the sterol composition of Saccharomyces cerevisiae sterol auxotroph strain FY-14 was modified and sensitivity to syringomycin E examined. Cells containing solely ergosterol, cholesterol, beta-sitosterol or stigmasterol were sensitive to syringomycin E with the latter two being the most sensitive. Cells containing growth-promoting cholesterol were the most sensitive and those with growth-promoting ergosterol the least sensitive. It is concluded that sensitivity to syringomycin E is modulated by growth-promoting sterols and does not necessarily require ergosterol. (C) 1998 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：215 / 220

页数：6

共 13 条

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