Gene-gene interaction analyses between NMDA receptor subunit and dopamine receptor gene variants and clozapine response

被引：5

作者：

Hwang, Rudi ^{[1
]}

Souza, Renan P. ^{[1
]}

Tiwari, Arun K. ^{[1
]}

Zai, Clement C. ^{[1
]}

Mueller, Daniel J. ^{[1
]}

Potkin, Steven G. ^{[2
]}

Lieberman, Jeffrey A. ^{[3
]}

Meltzer, Herbert Y. ^{[4
]}

Kennedy, James L. ^{[1
]}

机构：

[1] Ctr Addict & Mental Hlth, Neurogenet Sect, Toronto, ON ST1R8, Canada

[2] Univ Calif Irvine, Brain Imaging Ctr, Irvine, CA 92697 USA

[3] New York State Psychiat Inst & Hosp, New York, NY 10032 USA

[4] Vanderbilt Univ, Med Ctr, Nashville, TN 37212 USA

来源：

PHARMACOGENOMICS | 2011年 / 12卷 / 02期

关键词：

antipsychotic; response; association; study; clozapine; dopamine; receptor gene; gene-gene interaction; GRIN1; GRIN2A; GRIN2B; NMDA receptor; subunit gene schizophrenia; METHYL-D-ASPARTATE; TREATMENT-RESISTANT SCHIZOPHRENIA; ANTIPSYCHOTIC-DRUGS; PROMOTER REGION; D-3; RECEPTOR; GRIN1; GENE; POSSIBLE ASSOCIATION; HETERO-DIMERIZATION; G1001C POLYMORPHISM; HUMAN STRIATUM;

D O I：

10.2217/PGS.10.182

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aims: To investigate the possible association and gene gene interaction effects of polymorphisms in NMDA receptor subunit (GRIN1, GRIN2A and GRIN2B) and dopamine receptor (DRD1, DRD2 and DRD3) genes with clozapine response. Materials & methods: GRIN1 rs11146020 (G1001C), GRIN2A GI-repeat and GRIN2B rs10193895 (G-200T) polymorphisms were tested for association in a Caucasian (n = 183) and an African American (n = 49) sample using chi(2) and ANOVA tests. Logistic regression and two-way ANOVA were used to explore gene gene interaction effects with dopamine receptor gene variants. Results & conclusion: This study does not support the involvement of the NMDA receptor subunit gene polymorphisms in clozapine response. All tests for an association were negative. Gene gene interaction analyses however yielded promising leads, including an observed effect between DRD1 rs686 and DRD3 Ser9Gly polymorphisms on clozapine response (p = 0.002).

引用

页码：277 / 291

页数：15

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