Epidemiological features of nosocomial Klebsiella pneumoniae: virulence and resistance determinants

被引：7

作者：

Zafer, Mai M. ^{[1
]}

El Bastawisie, Maha M. ^{[1
]}

Wassef, Mona ^{[2
]}

Hussein, Amira F. A. ^{[2
]}

Ramadan, Mohammed A. ^{[3
]}

机构：

[1] Ahram Canadian Univ, Dept Microbiol & Immunol, Fac Pharm, Cairo, Egypt

[2] Cairo Univ, Clin & Chem Pathol Dept, Fac Med, Cairo, Egypt

[3] Cairo Univ, Dept Microbiol & Immunol, Fac Pharm, Cairo, Egypt

来源：

FUTURE MICROBIOLOGY | 2022年 / 17卷 / 01期

关键词：

capsular type K2; CTX-M-15; hvKp; K; pneumoniae; multidrug resistance; OXA-48; RMPA2; ST147; SPECTRUM BETA-LACTAMASES; MULTIPLEX PCR; CARBAPENEM RESISTANCE; CLINICAL INFECTIONS; ENTEROBACTERIACEAE; GENES; EMERGENCE; PREVALENCE; RMPA; K1;

D O I：

10.2217/fmb-2021-0092

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aim: The authors aimed to examine antibiotic resistance genes and representative virulence determinants among 100 Klebsiella pneumoniae isolates with an emphasis on capsular serotypes and clonality of some of the isolates. Methods: PCR amplification of (rmpA, rmpA2, iutA, iroN and IncHI1B plasmid) and (NDM, OXA-48, KPC, CTX-M-15, VIM, IMP, SPM) was conducted. Wzi sequencing and multilocus sequence typing (MLST) were performed. Results: K2 was the only detected serotype in the authors' collection. RMPA2 was the most common capsule-associated virulence gene detected. All studied isolates harbored OXA-48-like (100%) and NDM (43%) (n = 43). ST147 was the most common sequence type. Conclusion: This work provides insight into the evolution of the coexistence of virulence and resistance genes in a tertiary healthcare setting in Cairo, Egypt.

引用

页码：27 / 40

页数：14

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