May autophagy be a novel biomarker and antitumor target in colorectal cancer?

被引：20
作者：
Gil, Justyna [1 ]
Pesz, Karolina A. [1 ]
Sasiadek, Maria M. [1 ]
机构：
[1] Wroclaw Med Univ, Dept Genet, Wroclaw, Poland
来源：
BIOMARKERS IN MEDICINE | 2016年 / 10卷 / 10期
关键词：
ATG; autophagy; autophagosome; BECN1; colorectal cancer; gene expression; immunohistochemistry; LC3; protein expression; INFLAMMATORY-BOWEL-DISEASE; COLON-CANCER; MICROSATELLITE INSTABILITY; FAVORABLE PROGNOSIS; DOWN-REGULATION; CROHNS-DISEASE; CELL-DEATH; BECLIN; EXPRESSION; APOPTOSIS;
D O I：
10.2217/bmm-2016-0083
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Autophagy is a catabolic process associated with intracellular self-digestion of damaged organelles or redundant proteins enabling maintenance of cell homeostasis. It is accepted that impaired autophagy is closely linked to cancer development and has been extensively studied in a variety of malignancies including colorectal cancer (CRC) to elucidate its influence on carcinogenesis, metastasis and antitumor therapy response. CRC remains a great epidemiological problem because of poor 5-year survival and treatment resistance. Many studies concerning autophagy in CRC gave inconsistent and contradictory results, illustrating a multifaceted nature of this process. In this review, we focus on current knowledge of autophagy in CRC development to determinate its role as a potential prognostic and predictive biomarker as well as target in antitumor therapy.
引用
收藏
页码：1081 / 1094
页数：14
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