Update on Antithrombotic Therapy after Percutaneous Coronary Intervention

被引：31

作者：

Saito, Yuichi ^{[1
,2
]}

Kobayashi, Yoshio ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Cardiovasc Med, Chiba, Japan

[2] Yale Sch Med, New Haven, CT 06510 USA

来源：

INTERNAL MEDICINE | 2020年 / 59卷 / 03期

关键词：

antithrombotic therapy; dual antiplatelet therapy; percutaneous coronary intervention; DUAL ANTIPLATELET THERAPY; ELUTING STENT IMPLANTATION; ELEVATION MYOCARDIAL-INFARCTION; OPTICAL COHERENCE TOMOGRAPHY; ANTICOAGULANT-THERAPY; RISK STRATIFICATION; CLINICAL-OUTCOMES; JAPANESE PATIENTS; BLEEDING EVENTS; FOCUSED UPDATE;

D O I：

10.2169/internalmedicine.3685-19

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Percutaneous coronary intervention (PCI) has become a standard-of-care procedure in the setting of angina or acute coronary syndrome. Antithrombotic therapy is the cornerstone of pharmacological treatment aimed at preventing ischemic events following PCI. Dual antiplatelet therapy as the combination of aspirin and P2Y(12) inhibitor has been proven to decrease stent-related thrombotic risks. However, the optimal duration of dual antiplatelet therapy, an appropriate P2Y(12) inhibitor, and the choice of aspirin versus P2Y(12) inhibitor as single antiplatelet therapy remain controversial. Furthermore, the combined use of oral anticoagulation in addition to antiplatelet therapy is a complex issue in clinical practice, such as in patients with atrial fibrillation. The key challenge concerning the optimal antithrombotic regimen is ensuring a balance between protection against thrombotic events and against excessive increases in bleeding risk. In this review article, we summarize the current evidence concerning antithrombotic therapy in patients with coronary artery disease undergoing PCI.

引用

页码：311 / 321

页数：11

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