Junctional complexes in epithelial cells: sentinels for extracellular insults and intracellular homeostasis

被引：20

作者：

Fu, Rong ^{[1
]}

Jiang, Xiaowan ^{[1
]}

Li, Gang ^{[1
]}

Zhu, Yi ^{[1
]}

Zhang, Huimin ^{[1
]}

机构：

[1] Soochow Univ, Inst Biol & Med Sci, Jiangsu Key Lab Infect & Immun, Suzhou 215123, Peoples R China

来源：

FEBS JOURNAL | 2022年 / 289卷 / 23期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

adherens junction; autophagy; desmosome; epithelium; hemidesmosome; innate immunity; proteostasis; stress resistance; tight junction; NF-KAPPA-B; MUCOSAL BARRIER FUNCTION; INTEGRIN-LINKED KINASE; ALPHA-CATENIN; E-CADHERIN; ADHERENS JUNCTIONS; TUMOR-SUPPRESSOR; TIGHT JUNCTIONS; TYROSINE PHOSPHORYLATION; HEMIDESMOSOMAL PLAQUE;

D O I：

10.1111/febs.16174

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cell-cell and cell-ECM junctions within the epithelial tissues are crucial anchoring structures that provide architectural stability, mechanical resistance, and permeability control. Their indispensable role as signaling hubs orchestrating cell shape-related changes such as proliferation, differentiation, migration, and apoptosis has also been well recognized. However, growing amount of evidence now suggests that the multitasking nature of epithelial junctions extends well beyond anchorage-dependent or cell shape change-related biological processes. In this review, we discuss the emerging roles of junctional complexes in regulating innate immune defense, stress resistance, and intracellular proteostasis of the epithelial cells, with emphasis on the upstream regulation of epithelial junctions on various aspects of the epithelial barrier.

引用

页码：7314 / 7333

页数：20

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