Acoustic Analysis of Voice in Huntington's Disease Patients

被引：32
作者：
Velasco Garcia, Maria Jesus [1 ]
Cobeta, Ignacio [2 ]
Martin, Gonzalo [1 ]
Alonso-Navarro, Hortensia [3 ]
Javier Jimenez-Jimenez, Felix [3 ]
机构：
[1] Na Sa Sonsoles Hosp, Serv Otolaryngol ENT, Avila, Spain
[2] Ramon y Cajal Univ Hosp, Serv Otolaryngol ENT, Madrid, Spain
[3] Del Sureste Hosp, Neurol Sect, Madrid, Spain
来源：
JOURNAL OF VOICE | 2011年 / 25卷 / 02期
关键词：
Huntington's disease; Voice; Acoustic analysis; NEUROLOGIC DISEASE; PARKINSONS-DISEASE; DISORDERS;
D O I：
10.1016/j.jvoice.2009.08.007
中图分类号：
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号：
100104 ; 100213 ;
摘要：
Background/Objectives. Alterations of voice and speech are frequently observed in Huntington's disease (HD). The aim of this study was to assess the degree of voice and speech abnormalities in a group of patients with HD and to analyze possible correlations with degree of disease severity. Patients/Methods. An observational study was carried out on diagnosed cases and controls. The voices of 20 patients were analyzed and compared with an age- and sex-matched control group. Variables analyzed included subjective voice exploration, analysis of aerodynamic efficiency, acoustic analysis measures, and laryngeal examination descriptions. Results obtained were correlated with degree of disease severity. Results. Changes in the Voice Handicap Index and clinical characteristics of the voice were observed. Maximum phonation time was reduced. Acoustic analysis revealed changes that were analyzed. Uncontrolled adduction-abduction movements were observed by laryngeal examination. All results showed a positive correlation with degree of disease severity assessed by the Unified Huntington's Disease Rating Scale. Conclusions. HD causes alterations in subjective voice features, aerodynamic and acoustic analysis measures that are correlated with disease severity.
引用
收藏
页码：208 / 217
页数：10
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