Regulation and Evasion of Host Immune Response by African Swine Fever Virus

被引:10
|
作者
Wu, Lei [1 ]
Yang, Bincai [1 ]
Yuan, Xu [1 ]
Hong, Jinxuan [1 ]
Peng, Min [1 ]
Chen, Ji-Long [1 ]
Song, Zhongbao [1 ]
机构
[1] Fujian Agr & Forestry Univ, Coll Anim Sci, Key Lab Fujian Taiwan Anim Pathogen Biol, Fuzhou, Peoples R China
关键词
African swine fever virus; regulation; immune response; interferon; inflammation; apoptosis; DOMESTIC PIGS; CATALYTIC SUBUNIT; DENDRITIC CELLS; BCL-2; HOMOLOG; GENE; VIRULENCE; ISOLATE; EXPRESSION; PROTECTION; INFECTION;
D O I
10.3389/fmicb.2021.698001
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
African swine fever (ASF) is an acute lethal hemorrhagic viral disease in domestic pigs and wild boars; is widely epidemic in Africa, Europe, Asia, and Latin America; and poses a huge threat to the pig industry worldwide. ASF is caused by the infection of the ASF virus (ASFV), a cytoplasmic double-stranded DNA virus belonging to the Asfarviridae family. Here, we review how the virus regulates the host immune response and its mechanisms at different levels, including interferon modulation, inflammation, apoptosis, antigen presentation, and cellular immunity.</p>
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页数:9
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