An androgenic steroid delivery vector that imparts activity to a non-conventional platinum(II) metallo-drug

被引：59

作者：

Huxley, Martin ^{[1
]}

Sanchez-Cano, Carlos ^{[2
]}

Browning, Michael J. ^{[1
]}

Navarro-Ranninger, Carmen ^{[3
]}

Quiroga, Adoracion G. ^{[1
,3
]}

Rodger, Alison ^{[1
]}

Hannon, Michael J. ^{[1
,2
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

[2] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England

[3] Univ Autonoma Madrid, Dept Quim Inorgan, Madrid, Spain

来源：

DALTON TRANSACTIONS | 2010年 / 39卷 / 47期

基金：

英国生物技术与生命科学研究理事会;

关键词：

ESTROGEN-RECEPTOR-ALPHA; BREAST-CANCER; ESTRADIOL DERIVATIVES; PROGESTERONE-RECEPTORS; CELLULAR PHARMACOLOGY; BINDING-AFFINITY; OVARIAN-CANCER; MCF-7; CELLS; RAT UTERUS; COMPLEXES;

D O I：

10.1039/c0dt00838a

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A range of androgen conjugates with non-conventional platinum(II) complexes have been synthesised with the aim of targeting tumour cells since many display elevated levels of the androgen receptor. The androgenic platinum conjugates are delivered into selected cells with improved efficiency (when compared to their non-steroidal analogues). The act of conjugating an androgen to a platinum(II) complex resulted in synergistic effects between the metallic centre and the steroidal ligand, creating highly potent platinum(II) complexes from the inactive components.

引用

页码：11353 / 11364

页数：12

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