Metabolic syndrome status over 2 years predicts incident chronic kidney disease in mid-life adults: a 10-year prospective cohort study

被引：16
作者：
Lee, So Jin [1 ]
Lee, Hun Ju [1 ]
Oh, Hyun Jeong [1 ]
Go, Taehwa [2 ]
Kang, Dae Ryong [2 ]
Kim, Jang Young [3 ]
Huh, Ji Hye [3 ]
机构：
[1] Yonsei Univ, Wonju Coll Med, Wonju, South Korea
[2] Yonsei Univ, Wonju Coll Med, Ctr Biomed Data Sci, Wonju, South Korea
[3] Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju, South Korea
来源：
SCIENTIFIC REPORTS | 2018年 / 8卷
关键词：
NUTRITION EXAMINATION SURVEY; KOREAN NATIONAL-HEALTH; STAGE RENAL-DISEASE; TERM-FOLLOW-UP; CARDIOVASCULAR-DISEASE; LIFE-STYLE; DIABETES PREVENTION; RISK; ASSOCIATION; PROGRESSION;
D O I：
10.1038/s41598-018-29958-7
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We investigated whether changes in MetS status over two years modify the 10-year risk of CKD and proteinuria. A prospective cohort study was conducted in 7,251 subjects without CKD at baseline. We categorized subjects according to MetS status over two years: non-MetS (no MetS at either visit), intermittent MetS (positive for MetS at one assessment), and persistent MetS (positive for MetS at two assessments). The hazard ratio (HR) of new-onset CKD over 10-year was calculated using Cox models. During the 10-year follow-up period, 923 (12.7%) developed CKD. Compared to the non-MetS group, the fully adjusted HR for new-onset CKD was the highest in the persistent MetS group (HR, 1.53; 95% CI, 1.23-1.90), followed by the intermittent MetS group (HR, 1.29; 95% CI, 1.04-1.59) (P for trend <0.001). The HR for developing proteinuria was 1.79 (95% CI, 1.15-2.79) in the persistent MetS group and 0.70 (95% CI, 0.42-1.19) in the intermittent MetS group when the non-MetS group was considered as the reference group. Temporal changes in MetS status over two years influenced the 10-year risk of incident CKD and proteinuria. Our findings suggest that monitoring and strictly controlling MetS are important in preventing renal function decline.
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页数：7
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