Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer

被引：91

作者：

Kim, Dong-Hyun ^{[3
]}

Smith-Warner, Stephanie A. ^{[1
,2
]}

Spiegelman, Donna ^{[1
,4
]}

Yaun, Shiaw-Shyuan ^{[2
]}

Colditz, Graham A. ^{[6
]}

Freudenheim, Jo L. ^{[9
]}

Giovannucci, Edward ^{[1
,2
,7
,8
]}

Goldbohm, R. Alexandra ^{[10
]}

Graham, Saxon ^{[9
]}

Harnack, Lisa ^{[11
]}

Jacobs, Eric J. ^{[12
]}

Leitzmann, Michael ^{[13
]}

Mannisto, Satu ^{[15
]}

Miller, Anthony B. ^{[16
]}

Potter, John D. ^{[17
]}

Rohan, Thomas E. ^{[18
]}

Schatzkin, Arthur ^{[14
]}

Speizer, Frank E. ^{[5
,7
,8
]}

Stevens, Victoria L. ^{[12
]}

Stolzenberg-Solomon, Rachael

Terry, Paul ^{[19
]}

Toniolo, Paolo ^{[22
]}

Weijenberg, Matty P. ^{[20
]}

Willett, Walter C. ^{[1
,2
,7
,8
]}

Wolk, Alicja ^{[21
]}

Zeleniuch-Jacquotte, Anne ^{[22
]}

Hunter, David J. ^{[1
,2
,7
,8
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[3] Hallym Univ, Dept Social & Prevent Med, Coll Med, Chunchon, South Korea

[4] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

[5] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA

[6] Washington Univ, Sch Med, Inst Publ Hlth, St Louis, MO USA

[7] Brigham & Womens Hosp, Channing Lab, Dept Med, Boston, MA 02115 USA

[8] Harvard Univ, Sch Med, Boston, MA USA

[9] SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA

[10] TNO Qual Life, Dept Prevent & Hlth, Leiden, Netherlands

[11] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA

[12] Amer Canc Soc, Atlanta, GA 30329 USA

[13] Univ Regensburg, Inst Epidemiol & Prevent Med, Regensburg, Germany

[14] NCI, Nutr Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Bethesda, MD 20892 USA

[15] Natl Publ Hlth Inst, Dept Hlth Promot & Chron Dis Prevent, Helsinki, Finland

[16] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

[17] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Serv, Seattle, WA 98104 USA

[18] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA

[19] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA

[20] Maastricht Univ, Dept Epidemiol, Sch Oncol & Dev Biol GROW, Maastricht, Netherlands

[21] Karolinska Inst, Div Nutr Epidemiol, Natl Inst Environm Med, Stockholm, Sweden

[22] NYU, Dept Environm Med, New York, NY 10016 USA

来源：

CANCER CAUSES & CONTROL | 2010年 / 21卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Colon cancer; Folate; Cohort studies; Meta-analysis; Pooled analysis; FOOD FREQUENCY QUESTIONNAIRE; NESTED CASE-CONTROL; COLORECTAL-CANCER; DNA METHYLATION; DIETARY-FOLATE; UNITED-STATES; FOLIC-ACID; SUPPLEMENT USE; RISK-FACTORS; POSTMENOPAUSAL WOMEN;

D O I：

10.1007/s10552-010-9620-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Studies of folate intake and colorectal cancer risk have been inconsistent. We examined the relation with colon cancer risk in a series of 13 prospective studies. Study- and sex-specific relative risks (RRs) were estimated from the primary data using Cox proportional hazards models and then pooled using a random-effects model. Among 725,134 participants, 5,720 incident colon cancers were diagnosed during follow-up. The pooled multivariate RRs (95% confidence interval [CI]) comparing the highest vs. lowest quintile of intake were 0.92 (95% CI 0.84-1.00, p-value, test for between-studies heterogeneity = 0.85) for dietary folate and 0.85 (95% CI 0.77-0.95, p-value, test for between-studies heterogeneity = 0.42) for total folate. Results for total folate intake were similar in analyses using absolute intake cutpoints (pooled multivariate RR = 0.87, 95% CI 0.78-0.98, comparing a parts per thousand yen560 mcg/days vs. < 240 mcg/days, p-value, test for trend = 0.009). When analyzed as a continuous variable, a 2% risk reduction (95% CI 0-3%) was estimated for every 100 mu g/day increase in total folate intake. These data support the hypothesis that higher folate intake is modestly associated with reduced risk of colon cancer.

引用

页码：1919 / 1930

页数：12

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