ECM1 controls TH2 cell egress from lymph nodes through re-expression of S1P1

被引：46

作者：

Li, Zhenhu ^{[1
]}

Zhang, Yuan ^{[1
]}

Liu, Zhiduo ^{[1
]}

Wu, Xiaodong ^{[1
]}

Zheng, Yuhan ^{[1
]}

Tao, Zhiyun ^{[1
]}

Mao, Kairui ^{[1
]}

Wang, Jie ^{[1
]}

Lin, Guomei ^{[1
]}

Tian, Lin ^{[1
]}

Ji, Yongyong ^{[1
]}

Qin, Meiling ^{[1
]}

Sun, Shuhui ^{[2
]}

Zhu, Xueliang ^{[1
]}

Sun, Bing ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai, Peoples R China

[2] Fudan Univ, Sch Med, Shanghai 200433, Peoples R China

[3] Chinese Acad Sci, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Mol Virus Unit, Shanghai, Peoples R China

来源：

NATURE IMMUNOLOGY | 2011年 / 12卷 / 02期

基金：

中国国家自然科学基金;

关键词：

MATRIX PROTEIN-1 ECM1; T-CELLS; SPHINGOSINE-1-PHOSPHATE; TRAFFICKING; RECEPTOR; MOUSE; DIFFERENTIATION; EXPRESSION; INDUCTION; MIGRATION;

D O I：

10.1038/ni.1983

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type 2 helper T cells (T(H)2) are critically involved in allergies and asthma. Here we demonstrate that extracellular matrix protein-1 (ECM1) is highly and selectively expressed in T(H)2 cells. ECM1 deficiency caused impaired T(H)2 responses and reduced allergic airway inflammation in vivo. Functional analysis demonstrated that although the T(H)2 polarization of ECM1-deficient cells was unimpaired, these cells had a defect in migration and were retained in peripheral lymphoid organs. This was associated with reduced expression of KLF2 and S1P(1). We also found that ECM1 could directly bind the interleukin-2 (IL-2) receptor to inhibit IL-2 signaling and activate S1P(1) expression. Our data identify a previously unknown function of ECM1 in regulating T(H)2 cell migration through control of KLF2 and S1P(1) expression.

引用

页码：178 / U95

页数：9

共 36 条

[1] Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration [J].

Allende, ML ;

Dreier, JL ;

Mandala, S ;

Proia, RL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (15) :15396-15401

[2] MOLECULAR-CLONING, CHARACTERIZATION, AND GENETIC-MAPPING OF THE CDNA CODING FOR A NOVEL SECRETORY PROTEIN OF MOUSE - DEMONSTRATION OF ALTERNATIVE SPLICING IN SKIN AND CARTILAGE [J].

BHALERAO, J ;

TYLZANOWSKI, P ;

FILIE, JD ;

KOZAK, CA ;

MERREGAERT, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (27) :16385-16394

[3] The immune modulator FTY720 targets sphingosine 1-phosphate receptors [J].

Brinkmann, V ;

Davis, MD ;

Heise, CE ;

Albert, R ;

Cottens, S ;

Hof, R ;

Bruns, C ;

Prieschl, E ;

Baumruker, T ;

Hiestand, P ;

Foster, CA ;

Zollinger, M ;

Lynch, KR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (24) :21453-21457

[4] Kruppel-like factor 2 regulates thymocyte and T-cell migration [J].

Carlson, Corey M. ;

Endrizzi, Bart T. ;

Wu, Jinghai ;

Ding, Xiaojie ;

Weinreich, Michael A. ;

Walsh, Elizabeth R. ;

Wani, Maqsood A. ;

Lingrel, Jerry B. ;

Hogquist, Kristin A. ;

Jameson, Stephen C. .

NATURE, 2006, 442 (7100) :299-302

[5] Cutting edge: Regulation of T cell trafficking and primary immune responses by sphingosine 1-phosphate receptor 1 [J].

Chi, HB ;

Flavell, RA .

JOURNAL OF IMMUNOLOGY, 2005, 174 (05) :2485-2488

[6] Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs [J].

Cyster, JG .

ANNUAL REVIEW OF IMMUNOLOGY, 2005, 23 :127-159

[7] Transcriptional regulation of mouse L-selectin [J].

Dang, Xitong ;

Raffler, Nikolai A. ;

Ley, Klaus .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2009, 1789 (02) :146-152

[8] TH 17 cells in development:: an updated view of their molecular identity and genetic programming [J].

Dong, Chen .

NATURE REVIEWS IMMUNOLOGY, 2008, 8 (05) :337-348

[9] Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells [J].

Graeler, M ;

Goetzl, EJ .

FASEB JOURNAL, 2002, 16 (14) :1874-1878

[10]

Grähler MH, 2005, J IMMUNOL, V174, P1997

← 1 2 3 4 →