Complicated skin and soft tissue infection

被引：268
作者：
Dryden, Matthew S. [1 ]
机构：
[1] Royal Hampshire Cty Hosp, Dept Microbiol, Winchester SO22 5DG, Hants, England
来源：
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2010年 / 65卷
关键词：
antibiotic treatment; MRSA; PVL; linezolid; daptomycin; tigecycline; moxifloxacin; RESISTANT STAPHYLOCOCCUS-AUREUS; ANTIMICROBIAL SURVEILLANCE PROGRAM; TRIMETHOPRIM-SULFAMETHOXAZOLE; WOUND INFECTIONS; LATIN-AMERICA; DOUBLE-BLIND; VANCOMYCIN; MANAGEMENT; SUSCEPTIBILITY; EFFICACY;
D O I：
10.1093/jac/dkq302
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Successful management of cSSTI involves prompt recognition, timely surgical debridement or drainage, resuscitation if required and appropriate antibiotic therapy. The mainstays of treatment are the penicillins, cephalosporins, clindamycin and co-trimoxazole. beta-Lactam/beta-lactamase inhibitor combinations are indicated for polymicrobial infection. A range of new agents for the treatment of methicillin-resistant S. aureus infections have compared favourably with the glycopeptides and some have distinct pharmacokinetic advantages. These include linezolid, daptomycin and tigecycline. The latter and fluoroquinolones with enhanced anti-Gram-positive activity such as moxifloxacin are better suited for polymicrobial infection.
引用
收藏
页码：iii35 / iii44
页数：10
相关论文
共 76 条
[1]   The safety and efficacy of daptomycin for the treatment of complicated skin and skin-structure infections [J].
Arbeit, RD ;
Maki, D ;
Tally, FP ;
Campanaro, E ;
Eisenstein, BI .
CLINICAL INFECTIOUS DISEASES, 2004, 38 (12) :1673-1681
[2]   Increasing incidence of methicillin-resistant Staphylococcus aureus skin and soft-tissue infections:: Reconsideration of empiric antimicrobial therapy [J].
Awad, Samir S. ;
Elhabash, Saleem I. ;
Lee, Liz ;
Farrow, Buckmister ;
Berger, David H. .
AMERICAN JOURNAL OF SURGERY, 2007, 194 (05) :606-610
[3]   Are the new quinolones appropriate treatment for community-acquired methicillin-resistant Staphylococcus aureus? [J].
Bo, SP ;
Zhao, XL ;
Kreiswirth, BN ;
Tillotson, GS ;
Drlica, K .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2004, 24 (01) :32-34
[4]  
Bruce AM, 2008, J DRUGS DERMATOL, V7, P751
[5]   Prospective randomized trial of empiric therapy with trimethoprim-sulfamethoxazole or doxycycline for outpatient skin and soft tissue infections in an area of high prevalence of methicillin-resistant Staphylococcus aureus [J].
Cenizal, Mary Jo ;
Skiest, Daniel ;
Luber, Samuel ;
Bedimo, Roger ;
Davis, Pat ;
Fox, Patrick ;
Delaney, Kathleen ;
Hardy, R. Doug .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (07) :2628-2630
[6]   Survey of infections due to Staphylococcus species:: Frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillance Program, 1997-1999 [J].
Diekema, DJ ;
Pfaller, MA ;
Schmitz, FJ ;
Smayevsky, J ;
Bell, J ;
Jones, RN ;
Beach, M .
CLINICAL INFECTIOUS DISEASES, 2001, 32 :S114-S132
[7]   Complicated infections of skin and skin structures: when the infection is more than skin deep [J].
DiNubile, MJ ;
Lipsky, BA .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2004, 53 :37-50
[8]   VIBRIO-DAMSELA WOUND INFECTIONS IN AUSTRALIA [J].
DRYDEN, M ;
LEGARDE, M ;
GOTTLIEB, T ;
BRADY, L ;
GHOSH, HK .
MEDICAL JOURNAL OF AUSTRALIA, 1989, 151 (09) :540-541
[9]   A European survey of antibiotic management of methicillin-resistant Staphylococcus aureus infection: current clinical opinion and practice [J].
Dryden, M. ;
Tambic Andrasevic, Arjana ;
Bassetti, M. ;
Bouza, E. ;
Chastre, J. ;
Cornaglia, G. ;
Esposito, S. ;
French, G. ;
Giamarellou, H. ;
Gyssens, I. C. ;
Nathwani, D. ;
Unal, S. ;
Voss, A. .
CLINICAL MICROBIOLOGY AND INFECTION, 2010, 16 :3-30
[10]   Complicated Skin and Soft Tissue Infections Caused by Methicillin-Resistant Staphylococcus aureus: Epidemiology, Risk Factors, and Presentation [J].
Dryden, Matthew .
SURGICAL INFECTIONS, 2008, 9 :S3-S10
12345678