Dietary fiber-derived short-chain fatty acids: A potential therapeutic target to alleviate obesity-related nonalcoholic fatty liver disease

被引：159

作者：

Zhang, Shumin ^{[1
]}

Zhao, Jingwen ^{[2
]}

Xie, Fei ^{[3
]}

He, Hengxun ^{[1
]}

Johnston, Lee J. ^{[4
]}

Dai, Xiaofeng ^{[3
]}

Wu, Chaodong ^{[5
]}

Ma, Xi ^{[1
]}

机构：

[1] China Agr Univ, Coll Anim Sci & Technol, State Key Lab Anim Nutr, Beijing 100193, Peoples R China

[2] Tianjin Med Univ, Dept Gastroenterol & Hepatol, Gen Hosp, Tianjin, Peoples R China

[3] Chinese Acad Agr Sci, Feed Res Inst, Key Lab Feed Biotechnol, Minist Agr, Beijing, Peoples R China

[4] Univ Minnesota, West Cent Res & Outreach Ctr, Morris, MN 56267 USA

[5] Texas A&M Univ, Dept Nutr & Food Sci, College Stn, TX 77843 USA

来源：

OBESITY REVIEWS | 2021年 / 22卷 / 11期

基金：

中国国家自然科学基金;

关键词：

dietary fiber; gut-liver axis; NAFLD; SCFAs; KAPPA-B PATHWAY; GUT MICROBIOTA; PHELLINUS-LINTEUS; INSULIN-RESISTANCE; NLRP3; INFLAMMASOME; RECEPTOR; BUTYRATE; PROPIONATE; BACTERIA; BARRIER;

D O I：

10.1111/obr.13316

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Over the past several decades, increasing global prevalence of obesity-related nonalcoholic fatty liver disease (NAFLD) has been one of main challenges to human health. Recently, increasing evidence has validated connections among short chain fatty acids (SCFAs), a physiologically relevant concentration, the intestinal microbiota, and host metabolism. In this review, we summarized crosstalk between SCFAs and host metabolism in relation to NAFLD pathophysiology, focusing on recent advances. Firstly, how SCFAs are generated and absorbed under different nutritional conditions in the gut. Secondly, how SCFAs maintain gut barrier and alleviate hepatic inflammatory responses. Thirdly, how SCFAs maintain hepatic energy balance through controlling appetite and mediating the glucose homeostasis at the systemic level. Fourthly, G-protein-coupled receptors (GPRs) are widely involved in the above metabolic processes regulated by SCFAs. Overall, this review aimed to provide new insights into the prospects of SCFAs as a potential therapeutic target in management of liver diseases.

引用

页数：15

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