Genetic confirmation of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to East Africa

被引：61

作者：

Schwartz, E

Bujanover, S

Kain, KC

机构：

[1] Toronto Gen Hosp, Dept Med, Div Infect Dis, Trop Dis Unit, Toronto, ON M5G 2C4, Canada

[2] Chaim Sheba Med Ctr, Ctr Geog Med, IL-52621 Tel Hashomer, Israel

[3] Chaim Sheba Med Ctr, Dept Med, IL-52621 Tel Hashomer, Israel

[4] Univ Toronto, Toronto, ON, Canada

来源：

CLINICAL INFECTIOUS DISEASES | 2003年 / 37卷 / 03期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1086/375599

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report a case of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to Kenya. Recurrent parasitemia occurred 30 days after directly observed therapy with a combination of atovaquone and proguanil. Treatment failure was confirmed by genetic fingerprinting and sequencing. The primary isolate had wild-type sequence of cytochrome b; however, the recrudescent isolate had a single mutation at position 268 (Tyr268Ser).

引用

页码：450 / 451

页数：2

共 9 条

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