Noncontact fluorescence diffuse optical tomography off heterogeneous media

被引：62

作者：

Herve, L. ^{[1
]}

Koenig, A. ^{[1
]}

Da Silva, A. ^{[1
]}

Berger, M. ^{[1
]}

Boutet, J. ^{[1
]}

Dinten, J. M. ^{[1
]}

Peltie, P. ^{[1
]}

Rizo, P. ^{[1
]}

机构：

[1] MINATEC, CEA, LETI, F-38054 Grenoble, France

来源：

APPLIED OPTICS | 2007年 / 46卷 / 22期

关键词：

Animals - Fluorescence - Mathematical models - Tumors;

D O I：

10.1364/AO.46.004896

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Fluorescence-enhanced diffuse optical tomography is expected to be useful to the collection of functional information from small animal models. This technique is currently limited by the extent of tissue heterogeneity and management of the shape of the animals. We propose an approach based on the reconstruction of object heterogeneity, which provides an original solution to the two problems. Three evaluation campaigns are described: the first two were performed on phantoms designed to test the reconstructions in highly heterogeneous media and noncontact geometries; the third was conducted on mice with lung tumors to test fluorescence yield reconstruction feasibility in uivo. (c) 2007 Optical Society of America.

引用

页码：4896 / 4906

页数：11

共 23 条

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