Solid-phase synthesis of peptide thioesters with self-purification

被引：49

作者：

Mende, Franziska ^{[1
]}

Seitz, Oliver ^{[1
]}

机构：

[1] Humboldt Univ, Inst Chem, D-12489 Berlin, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 24期

关键词：

cyclization; native chemical ligation; peptides; solid-phase synthesis;

D O I：

10.1002/anie.200700356

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Separating the wheat from the chaff: A cyclization-thiolysis sequence adds a new property to sulfonamide safety-catch resins. Activation of the sulfonamide is used to introduce a carboxy group for subsequent macrocyclization. Truncation products are noncyclic and hence washed away following thiolytic ring opening. Only the full-length peptide thioesters are detached, usually in pure form, in the final step. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：4577 / 4580

页数：4

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