Virulence determinants in community and hospital meticillin-resistant Staphylococcus aureus

被引：87
作者：
Tristan, Anne [1 ]
Ferry, Tristan [1 ]
Durand, Geraldine [1 ]
Dauwalder, Olivier [1 ]
Bes, Michele [1 ]
Lina, Gerard [1 ]
Vandenesch, Francois [1 ]
Etienne, Jerome [1 ]
机构：
[1] Univ Lyon 1, Fac Med Laennec, INSERM E0230, Ctr Natl Reference Staphylocoques, F-69008 Lyon, France
来源：
JOURNAL OF HOSPITAL INFECTION | 2007年 / 65卷
关键词：
Staphylococcus aureus; virulence factors; superantigenic toxins; Panton Valentine leukocidin; meticillin resistance;
D O I：
10.1016/S0195-6701(07)60025-5
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Staphylococcus aureus produces many virulence factors, most of which act in a synergistic and coordinated fashion. Some appear to be specifically associated with certain severe infections and are produced by meticillin-resistant Staphylococcus aureus (MRSA) clones distributed worldwide. Superantigenic exotoxins appear to be major virulence factors in hospital MRSA clones (HA-MRSA), and staphylococcal enterotoxin A (SEA) may be involved in the physiopathology of septic shock. Panton Valentine Leucocidin (PVL) has emerged as a major virulence factor in community-acquired Staphylococcus aureus (CA-MRSA) infections. In particular, the Leukotoxic action of PVL is responsible for the high mortality rate associated with necrotizing pneumonia. CA-MRSA can also harbour the toxic shock toxin 1 (TSST-1) and rarely the exfoliative toxin. (C) 2007 The Hospital Infection Society. Published by Elsevier Ltd. Alt rights reserved.
引用
收藏
页码：105 / 109
页数：5
相关论文
共 26 条
  • [1] Genome and virulence determinants of high virulence community-acquired MRSA
    Baba, T
    Takeuchi, F
    Kuroda, M
    Yuzawa, H
    Aoki, K
    Oguchi, A
    Nagai, Y
    Iwama, N
    Asano, K
    Naimi, T
    Kuroda, H
    Cui, L
    Yamamoto, K
    Hiramatsu, K
    [J]. LANCET, 2002, 359 (9320) : 1819 - 1827
  • [2] Panton-Valentine leukocidin genes are associated with enhanced inflammatory response and local disease in acute hematogenous Staphylococcus aureus osteomyelitis in children
    Bocchini, CE
    Hulten, KG
    Mason, EO
    Gonzalez, BE
    Hammerman, WA
    Kaplan, SL
    [J]. PEDIATRICS, 2006, 117 (02) : 433 - 440
  • [3] Transmission of Panton-Valentine leukocidin-producing Staphylococcus aureus to a physician during resuscitation of a child
    Chalumeau, M
    Bidet, P
    Lina, G
    Mokhtari, M
    André, MC
    Gendrel, D
    Bingen, E
    Raymond, J
    [J]. CLINICAL INFECTIOUS DISEASES, 2005, 41 (03) : E29 - E30
  • [4] The genomic aspect of virulence, sepsis, and resistance to killing mechanisms in Staphylococcus aureus
    Cheung A.L.
    Projan S.J.
    Gresham H.
    [J]. Current Infectious Disease Reports, 2002, 4 (5) : 400 - 410
  • [5] STAPHYLOCOCCUS-AUREUS LEUKOCIDIN - A NEW VIRULENCE FACTOR IN CUTANEOUS INFECTIONS - AN EPIDEMIOLOGIC AND EXPERIMENTAL-STUDY
    CRIBIER, B
    PREVOST, G
    COUPPIE, P
    FINCKBARBANCON, V
    GROSSHANS, E
    PIEMONT, Y
    [J]. DERMATOLOGY, 1992, 185 (03) : 175 - 180
  • [6] Comparative inflammatory properties of staphylococcal superantigenic enterotoxins SEA and SEG: implications for septic shock
    Dauwalder, Olivier
    Thomas, Damien
    Ferry, Tristan
    Debard, Anne-Lise
    Badiou, Cedric
    Vandenesch, Francois
    Etienne, Jerome
    Lina, Gerard
    Monneret, Guillaume
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2006, 80 (04) : 753 - 758
  • [7] Exotoxins of Staphylococcus aureus
    Dinges, MM
    Orwin, PM
    Schlievert, PM
    [J]. CLINICAL MICROBIOLOGY REVIEWS, 2000, 13 (01) : 16 - +
  • [8] Detection of new methicillin-resistant Staphylococcus aureus clones containing the toxic shock syndrome toxin 1 gene responsible for hospital- and community-acquired infections in France
    Durand, G
    Bes, M
    Meugnier, H
    Enright, MC
    Forey, F
    Liassine, N
    Wenger, A
    Kikuchi, K
    Lina, G
    Vandenesch, F
    Etienne, J
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (03) : 847 - 853
  • [9] Comparative prevalence of superantigen genes in Staphylococcus aureus isolates causing sepsis with and without septic shock
    Ferry, T
    Thomas, D
    Genestier, AL
    Bes, M
    Lina, G
    Vandenesch, F
    Etienne, J
    [J]. CLINICAL INFECTIOUS DISEASES, 2005, 41 (06) : 771 - 777
  • [10] PORE FORMATION BY A 2-COMPONENT LEUKOCIDIN FROM STAPHYLOCOCCUS-AUREUS WITHIN THE MEMBRANE OF HUMAN POLYMORPHONUCLEAR LEUKOCYTES
    FINCKBARBANCON, V
    DUPORTAIL, G
    MEUNIER, O
    COLIN, DA
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1182 (03) : 275 - 282
123