Progress toward the total synthesis of callipeltin A (I):: Asymmetric synthesis of (3S,4R)-3,4-dimethylglutamine

被引：55

作者：

Liang, B ^{[1
]}

Carroll, PJ ^{[1
]}

Joullié, MM ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Xray Crystallog Facil, Philadelphia, PA 19104 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 26期

关键词：

D O I：

10.1021/ol006679t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] During the total synthesis of the novel cyclic depsipeptide callipeltin A (1), the unit (3S,4R)-3,4-dimethylglutamine, was successfully synthesized by asymmetric Michael addition and subsequent electrophilic azidation. The key feature of this approach is the generation of three adjacent stereogenic centers using the same camphorsultam chiral auxiliary.

引用

页码：4157 / 4160

页数：4

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