Anti-TNF-Related Leukocytoclastic Vasculitis in Ulcerative Colitis: A Case Report

被引：9

作者：

Giorgio, Valentina ^{[1
]}

Blasi, Elisa ^{[1
]}

Rigante, Donato ^{[1
,2
]}

Guerriero, Cristina ^{[3
]}

De Simone, Clara ^{[2
,3
]}

Fedele, Anna Laura ^{[4
]}

Stella, Giuseppe ^{[1
]}

Gasbarrini, Antonio ^{[2
,5
]}

Scaldaferri, Franco ^{[5
]}

机构：

[1] Fdn Policlin Univ A Gemelli IRCCS, Dept Life Sci & Global Hlth, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, I-00168 Rome, Italy

[3] Fdn Policlin Univ A Gemelli IRCCS, Inst Dermatol, I-00168 Rome, Italy

[4] Fdn Policlin Univ A Gemelli IRCCS, Inst Rheumatol, I-00168 Rome, Italy

[5] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, Dept Internal Med, I-00168 Rome, Italy

来源：

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2021年 / 18卷 / 13期

关键词：

leukocytoclastic vasculitis; ulcerative colitis; purpura; tumor necrosis factor; EXTRAINTESTINAL MANIFESTATIONS; CUTANEOUS VASCULITIS; ANTAGONISTS; INFLIXIMAB; THERAPIES; PATIENT; RISK;

D O I：

10.3390/ijerph18136711

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Background: The development of drugs directed against tumor necrosis factor (TNF)-alpha has dramatically modified the therapeutic approach to inflammatory bowel diseases: a larger use of such drugs has also led to a major knowledge about their adverse effects, especially on skin. The aim of this report was to describe a rare steroid-dependent form of leukocytoclastic vasculitis induced by an anti-TNF-alpha agent in a young woman with ulcerative colitis. Case presentation: A young girl with ulcerative colitis developed a form of leukocytoclastic vasculitis induced by an anti-TNF-alpha agent. Recurrent palpable purpuric lesions on her legs were the main cutaneous manifestation. Skin lesions were steroid-dependent, but improved after withdrawal of the anti-TNF-alpha agent and second-line immunosuppressant therapy. Conclusions: The need to develop specific recommendations to guide the use of medications for managing skin reactions induced by anti-TNF-alpha drugs is herein emphasized.

引用

页数：6

共 29 条

[1] Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease [J].

Baert, F ;

Noman, M ;

Vermeire, S ;

Van Assche, G ;

D'Haens, G ;

Carbonez, A ;

Rutgeerts, P .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (07) :601-608

[2]

Bernardes C, 2018, GASTROENT HEPAT-BARC, V41, P442, DOI [10.1016/j.gastrohep.2017.08.004, 10.1016/j.gastre.2018.06.011]

[3] Case Report: Systemic Small-Vessel Vasculitis in an Adolescent With Active Ulcerative Colitis [J].

Bouhuys, Marleen ;

Armbrust, Wineke ;

van Rheenen, Patrick F. .

FRONTIERS IN PEDIATRICS, 2021, 9

[4] Leukocytoclastic vasculitis in an adolescent with ulcerative colitis: Report of a case and review of the literature [J].

Butts, G. Tyler ;

Bishop, Phyllis R. ;

Wyatt, Julie P. ;

Nowicki, Michael J. .

SAGE OPEN MEDICAL CASE REPORTS, 2014, 2

[5] Cutaneous Vasculitis in a Patient with Crohn's Disease Treated with Adalimumab [J].

Cury, Didia B. ;

de Souza, Alexandre W. S. ;

Vianna, Giovanni A. ;

Odashiro, Danilo ;

Farias, Alex ;

Moss, Alan C. .

INFLAMMATORY BOWEL DISEASES, 2017, 23 (01) :E1-E2

[6] The effect of anti-tumor necrosis factor alpha agents on the outcome in pediatric uveitis of diverse etiologies [J].

Deitch, Iris ;

Amer, Radgonde ;

Tomkins-Netzer, Oren ;

Habot-Wilner, Zohar ;

Friling, Ronit ;

Neumann, Ron ;

Kramer, Michal .

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2018, 256 (04) :801-808

[7] Etanercept induces improvement of arthropathy in chronic infantile neurological cutaneous articular (CINCA) syndrome [J].

Federico, G ;

Rigante, D ;

Pugliese, AL ;

Ranno, O ;

Catania, S ;

Stabile, A .

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 2003, 32 (05) :312-314

[8] The yin and yang of TNF-α inhibition [J].

Fiorentino, David F. .

ARCHIVES OF DERMATOLOGY, 2007, 143 (02) :233-236

[9]

Gonzalez-Gay MA, 2005, CURR OPIN RHEUMATOL, V17, P56

[10] Childhood generalized pustular psoriasis: Successful long-term treatment with adalimumab [J].

Hansel, Katharina ;

Marietti, Rossella ;

Tramontana, Marta ;

Bianchi, Leonardo ;

Romita, Paolo ;

Giuffrida, Roberta ;

Stingeni, Luca .

DERMATOLOGIC THERAPY, 2020, 33 (03)

← 1 2 3 →