Isoliquiritigenin (ISL) and its Formulations: Potential Antitumor Agents

被引:55
作者
Zhao, Ting-Ting [1 ,2 ]
Xu, Yu-Qing [1 ,2 ]
Hu, Hui-Min [1 ,2 ]
Gong, Hai-Bin [1 ,2 ]
Zhu, Hai-Liang [1 ,2 ]
机构
[1] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China
[2] Xuzhou Cent Hosp, Xuzhou 221009, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
Isoliquiritigenin; antitumor; breast cancer; mechanisms; signaling pathway; formulation; CANCER STEM-CELLS; ANTIPROLIFERATIVE ACTIVITIES; GROWTH-INHIBITION; CYCLE ARREST; APOPTOSIS; COMPOUND; PROLIFERATION; DERIVATIVES; EXPRESSION; INDUCTION;
D O I
10.2174/0929867325666181112091700
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Isoliquiritigenin (2',4',4-trihydroxychalcone, ISL) is one of the most important chalcone compounds which is mainly derived from licorice root and many other plants. It exhibits a remarkable range of potent biological and pharmacological activities such as antioxi-dative, antitumor, antiaging, anti-inflammatory, anti-diabetic activities, etc. Numerous research teams have demonstrated that ISL posseses the ability to carry out antigrowth and proliferation in various cancer cells in vitro and in vivo. Meanwhile, the underlying mechanisms of ISL that inhibit cancer cell proliferation have not been well explored. However, the poor bioavailability and low water-soluble limit its clinical application. This review aims at providing a comprehensive overview of the pharmacology antitumor activity of ISL and its mechanisms in different malignancy especially in breast cancer cell line and summarize developments of formulation utilized to overcome the barrier between its delivery characteristics and application in clinics over the past 20 years.
引用
收藏
页码:6786 / 6796
页数:11
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