Kinetic Analysis of the Rate of Corneal Wound Healing in Otsuka Long-Evans Tokushima Fatty Rats, a Model of Type 2 Diabetes Mellitus

被引：16

作者：

Nagai, Noriaki ^{[1
]}

Murao, Takatoshi ^{[1
]}

Okamoto, Norio ^{[3
]}

Ito, Yoshimasa ^{[1
,2
]}

机构：

[1] Kinki Univ, Dept Pharm, Osaka 5778502, Japan

[2] Kinki Univ, Pharmaceut Res & Technol Inst, Osaka 5778502, Japan

[3] Hyogo Coll Med, Dept Ophthalmol, Nishinomiya, Hyogo 6638501, Japan

来源：

JOURNAL OF OLEO SCIENCE | 2010年 / 59卷 / 08期

关键词：

cornea; corneal wound healing; type 2 diabetes mellitus; glucose; Otsuka Long-Evans Tokushima fatty rat; NITRIC-OXIDE SYNTHASE; INSULIN-RESISTANCE; CLOSED VITRECTOMY; EPITHELIAL-CELLS; GLUCOSE; COMPLICATIONS; SERICIN; CLOSURE; NIDDM;

D O I：

10.5650/jos.59.441

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Diabetic keratopathy is a well-known ocular complication secondary to type 2 diabetes mellitus. In this study, we performed a kinetic analysis of corneal wound healing in Long-Evans rats (normal rat) and Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of type 2 diabetes mellitus. Corneal wound healing in 7-week-old normal rats was mostly complete 24 h after corneal epithelial abrasion, and the process of corneal wound healing took place according to an equation with a first-order rate constant. The rate of corneal wound healing in normal rats decreased with aging. The process of corneal wound healing in 38- and 60-week-old normal and OLETF rats occurred in two phases with rate constants for the first and second phases represented as alpha and beta, respectively. The alpha and beta values in 38- and 60-week-old OLETF rats were lower than those in normal rats of the corresponding age. Furthermore, a close relationship was observed between the corneal wound healing rate constant and plasma glucose levels in OLETF rats. The present studies suggest the sequence of events that occur following damage to the corneal surface in OLETF rats as a model animal for a human type 2 diabetes mellitus.

引用

页码：441 / 449

页数：9

共 43 条

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