The presence of dupA in helicobacter pylori is not significantly associated with duodenal ulceration in Belgium, South Africa, China, or North America

被引：73
作者：
Argent, Richard H.
Burette, Alain
Deyi, Veronique Y. Miendje
Atherton, John C.
机构：
[1] Univ Nottingham, Ctr Biomol Sci, Inst Infect Immun & Inflammat, Nottingham NG7 2RD, England
[2] Queens Med Ctr, Wolfson Digest Dis Ctr, Nottingham NG7 2UH, England
[3] Ctr Hosp Interreg Edith Cavell Site Basil, Dept Gastroenterol, Brussels, Belgium
[4] Ctr Hosp Univ Brugmann, Microbiol Lab, Brussels, Belgium
来源：
CLINICAL INFECTIOUS DISEASES | 2007年 / 45卷 / 09期
关键词：
D O I：
10.1086/522177
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A previous study suggested that Helicobacter pylori strains possessing dupA are positively associated with duodenal ulceration and negatively associated with gastric adenocarcinoma. We determined the prevalence of dupA in H. pylori strains recovered from 4 independent populations and found a significant association with gastric cancer but not with duodenal ulceration.
引用
收藏
页码：1204 / 1206
页数：3
相关论文
共 15 条
  • [1] Host cell responses to genotypically similar Helicobacter pylori isolates from United States and Japan
    Ando, T
    Peek, RM
    Lee, YC
    Krishna, U
    Kusugami, K
    Blaser, MJ
    [J]. CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2002, 9 (01) : 167 - 175
  • [2] Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori
    Argent, RH
    Kidd, M
    Owen, RJ
    Thomas, RJ
    Limb, MC
    Atherton, JC
    [J]. GASTROENTEROLOGY, 2004, 127 (02) : 514 - 523
  • [3] Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori
    Atherton, JC
    Peek, RM
    Tham, KT
    Cover, TL
    Blaser, MJ
    [J]. GASTROENTEROLOGY, 1997, 112 (01) : 92 - 99
  • [4] BLASER MJ, 1995, CANCER RES, V55, P2111
  • [5] Helicobacter pylori HopH (OipA) and bacterial pathogenicity:: Genetic and functional genomic analysis of hopH gene Polymorphisms
    Dossumbekova, Anar
    Prinz, Christian
    Mages, Joerg
    Lang, Roland
    Kusters, Johannes G.
    Van Vliet, Arnoud H. M.
    Reindl, Wolfgang
    Backert, Steffen
    Saur, Dieter
    Schmid, Roland M.
    Rad, Roland
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2006, 194 (10) : 1346 - 1355
  • [6] Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin
    Gerhard, M
    Lehn, N
    Neumayer, N
    Borén, T
    Rad, R
    Schepp, W
    Miehlke, S
    Classen, M
    Prinz, C
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (22) : 12778 - 12783
  • [7] Heterogeneity in the Helicobacter pylori vacA and cagA genes:: association with gastroduodenal disease in South Africa?
    Kidd, M
    Lastovica, AJ
    Atherton, JC
    Louw, JA
    [J]. GUT, 1999, 45 (04) : 499 - 502
  • [8] Duodenal ulcer promoting gene of Helicobacter pylori
    Lu, H
    Hsu, PI
    Graham, DY
    Yamaoka, Y
    [J]. GASTROENTEROLOGY, 2005, 128 (04) : 833 - 848
  • [9] Miehlke S, 2000, INT J CANCER, V87, P322, DOI 10.1002/1097-0215(20000801)87:3&lt
  • [10] 322::AID-IJC3&gt
12