Type 1 receptor parathyroid hormone (PTH1R) influences breast cancer cell proliferation and apoptosis induced by high levels of glucose

被引：10
|
作者：
Liang, Huasheng [1 ]
Zhong, Yuhua [1 ]
Huang, Yu [2 ]
Chen, Genben [3 ]
机构：
[1] Beihai Inst Endocrine & Metab Dis, Beihai 536000, Guangxi, Peoples R China
[2] Peoples Hosp Guangxi Zhuang Autonomous Reg, Dept Hepatobiliary Surg, Nanning 530021, Guangxi Zhuang, Peoples R China
[3] Chaoan Peoples Hosp, Dept Endocrinol, Chaoan 515638, Guangdong, Peoples R China
来源：
MEDICAL ONCOLOGY | 2012年 / 29卷 / 02期
关键词：
Type 1 receptor parathyroid hormone; SHZ-88; cells; High glucose; Cell viability; Apoptosis; PTH/PTHRP RECEPTOR; PROTEIN; PEPTIDE; PTHRP; PHYSIOLOGY;
D O I：
10.1007/s12032-011-9851-x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Increased breast cancer incidence parallels the increase in cases of type 2 diabetes. We investigated the effect of type 1 receptor parathyroid hormone (PTH1R) expression on viability and apoptosis of breast cancer cells exposed to high levels of glucose. Upregulation of PTH1R was detected in patients with invasive ductal carcinoma of the breast and diabetes. In vitro, PTH1R silencing suppressed cell proliferation and apoptosis induced by high levels of glucose by regulating Bax/Bcl-2 expression. These results suggest PTH1R silencing may represent a novel treatment approach for patients diagnosed with invasive ductal carcinoma of the breast who are also managing diabetes.
引用
收藏
页码：439 / 445
页数：7
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