Type 1 receptor parathyroid hormone (PTH1R) influences breast cancer cell proliferation and apoptosis induced by high levels of glucose

被引：10

作者：

Liang, Huasheng ^{[1
]}

Zhong, Yuhua ^{[1
]}

Huang, Yu ^{[2
]}

Chen, Genben ^{[3
]}

机构：

[1] Beihai Inst Endocrine & Metab Dis, Beihai 536000, Guangxi, Peoples R China

[2] Peoples Hosp Guangxi Zhuang Autonomous Reg, Dept Hepatobiliary Surg, Nanning 530021, Guangxi Zhuang, Peoples R China

[3] Chaoan Peoples Hosp, Dept Endocrinol, Chaoan 515638, Guangdong, Peoples R China

来源：

MEDICAL ONCOLOGY | 2012年 / 29卷 / 02期

关键词：

Type 1 receptor parathyroid hormone; SHZ-88; cells; High glucose; Cell viability; Apoptosis; PTH/PTHRP RECEPTOR; PROTEIN; PEPTIDE; PTHRP; PHYSIOLOGY;

D O I：

10.1007/s12032-011-9851-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Increased breast cancer incidence parallels the increase in cases of type 2 diabetes. We investigated the effect of type 1 receptor parathyroid hormone (PTH1R) expression on viability and apoptosis of breast cancer cells exposed to high levels of glucose. Upregulation of PTH1R was detected in patients with invasive ductal carcinoma of the breast and diabetes. In vitro, PTH1R silencing suppressed cell proliferation and apoptosis induced by high levels of glucose by regulating Bax/Bcl-2 expression. These results suggest PTH1R silencing may represent a novel treatment approach for patients diagnosed with invasive ductal carcinoma of the breast who are also managing diabetes.

引用

页码：439 / 445

页数：7

共 50 条

[1] Type 1 receptor parathyroid hormone (PTH1R) influences breast cancer cell proliferation and apoptosis induced by high levels of glucose
Huasheng Liang
Yuhua Zhong
Yu Huang
Genben Chen
Medical Oncology, 2012, 29 : 439 - 445
[2] Type 1 parathyroid hormone receptor (PTH1R) nuclear trafficking:: Association of PTH1R with importin α1 and β
Pickard, Bryce W.
Hodsman, Anthony B.
Fraher, Laurence J.
Watson, Patricia H.
ENDOCRINOLOGY, 2006, 147 (07) : 3326 - 3332
[3] Role of the Parathyroid Hormone Type 1 Receptor (PTH1R) as a Mechanosensor in Osteocyte Survival
Maycas, Marta
Ardura, Juan A.
de Castro, Luis F.
Bravo, Beatriz
Gortazar, Arancha R.
Esbrit, Pedro
JOURNAL OF BONE AND MINERAL RESEARCH, 2015, 30 (07) : 1231 - 1244
[4] Movements within the parathyroid hormone receptor (PTH1R) upon PTH binding
Thomas, B. E.
Wittelsberger, A.
Monaghan, P.
Mierke, D. F.
Rosenblatt, M.
JOURNAL OF BONE AND MINERAL RESEARCH, 2007, 22 : S83 - S83
[5] Parathyroid hormone acts on the PTH1R receptor in both osteoblasts and breast cancer cells to reduce bone metastases
Swami, Srilatha
Zhu, Hui
Nisco, Aria
Wu, Joy
JOURNAL OF BONE AND MINERAL RESEARCH, 2022, 37 : 266 - 266
[6] Role of primary cilia and parathyroid hormone (PTH) receptor type 1 (PTH1R) in osteocyte- osteoclast communication.
Tirado-Cabrera, Irene
Martin-Guerrero, Eduardo
Heredero-Jimenez, Sara
Buendia, Irene
Ardura, Juan A.
Gortazar, Arancha R.
JOURNAL OF BONE AND MINERAL RESEARCH, 2020, 35 : 194 - 194
[7] Type 1 parathyroid hormone receptor nuclear localization: Regulation of PTH1R nuclear trafficking by the importins.
Pickard, B. W.
Hodsman, A. B.
Fraher, L. J.
Watson, P. H.
JOURNAL OF BONE AND MINERAL RESEARCH, 2006, 21 : S199 - S199
[8] Type 1 parathyroid hormone receptor (PTH1R) nuclear trafficking:: Regulation of PTH1R nuclear-cytoplasmic shuttling by importin-α/β and chromosomal region maintenance 1/exportin 1
Pickard, Bryce W.
Hodsman, Anthony B.
Fraher, Laurence J.
Watson, Patricia H.
ENDOCRINOLOGY, 2007, 148 (05) : 2282 - 2289
[9] Physiological Role of Parathyroid Hormone-Related Protein (PTHrP) and Parathyroid Hormone-1 Receptor (PTH1R) Signaling in the Pancreatic β-Cell.
Zhang, Xiaoying
Guthalu, Nagesha K.
Williams, Katoura
Mozar, Anais
Rupangi, Vasavada
ENDOCRINE REVIEWS, 2010, 31 (03)
[10] VPS35: Two Ways to Recycle the Parathyroid Hormone Receptor (PTH1R) in Osteoblasts
Sims, Natalie A.
EBIOMEDICINE, 2016, 9 : 3 - +

← 1 2 3 4 5 →