Active chromatin and noncoding RNAs: an intimate relationship

被引：39

作者：

Flynn, Ryan A.

Chang, Howard Y. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2012年 / 22卷 / 02期

关键词：

CRYPTIC UNSTABLE TRANSCRIPTS; PERVASIVE TRANSCRIPTION; BIDIRECTIONAL PROMOTERS; DIVERGENT TRANSCRIPTION; GENE-EXPRESSION; S; CEREVISIAE; X-CHROMOSOME; ENHANCERS; GENOME; YEAST;

D O I：

10.1016/j.gde.2011.11.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Eukaryotic genomes are packaged into chromatin, where diverse histone modifications can demarcate chromatin domains that facilitate or block gene expression. While silent chromatin has been associated with long noncoding RNAs (IncRNAs) for some time, new studies suggest that noncoding RNAs also modulate the active chromatin state. Divergent, antisense, and enhancer-like intergenic noncoding RNAs can either activate or repress gene expression by altering histone H3 lysine 4 methylation. An emerging class of enhancer-like IncRNAs may link chromosome structure to chromatin state and establish active chromatin domains. The confluence of several new technologies promises to rapidly expand this fascinating topic of investigation.

引用

页码：172 / 178

页数：7

共 54 条

[1] Wilms Tumor Chromatin Profiles Highlight Stem Cell Properties and a Renal Developmental Network [J].

Aiden, Aviva Presser ;

Rivera, Miguel N. ;

Rheinbay, Esther ;

Ku, Manching ;

Coffman, Erik J. ;

Truong, Thanh T. ;

Vargas, Sara O. ;

Lander, Eric S. ;

Haber, Daniel A. ;

Bernstein, Bradley E. .

CELL STEM CELL, 2010, 6 (06) :591-602

[2] Termination of cryptic unstable transcripts is directed by yeast RNA-Binding proteins Nrd1 and Nab3 [J].

Arigo, John T. ;

Eyler, Daniel E. ;

Carroll, Kristina L. ;

Corden, Jeffry L. .

MOLECULAR CELL, 2006, 23 (06) :841-851

[3] A bivalent chromatin structure marks key developmental genes in embryonic stem cells [J].

Bernstein, BE ;

Mikkelsen, TS ;

Xie, XH ;

Kamal, M ;

Huebert, DJ ;

Cuff, J ;

Fry, B ;

Meissner, A ;

Wernig, M ;

Plath, K ;

Jaenisch, R ;

Wagschal, A ;

Feil, R ;

Schreiber, SL ;

Lander, ES .

CELL, 2006, 125 (02) :315-326

[4] A cryptic unstable transcript mediates transcriptional trans-silencing of the Ty1 retrotransposon in S. cerevisiae [J].

Berretta, Julia ;

Pinskaya, Marina ;

Morillon, Antonin .

GENES & DEVELOPMENT, 2008, 22 (05) :615-626

[5] RETRACTED: The Noncoding RNA Mistral Activates Hoxa6 and Hoxa7 Expression and Stem Cell Differentiation by Recruiting MLL1 to Chromatin (Retracted Article) [J].

Bertani, Stephane ;

Sauer, Silvia ;

Bolotin, Eugene ;

Sauer, Frank .

MOLECULAR CELL, 2011, 43 (06) :1040-1046

[6] Covalent modifications of histones during development and disease pathogenesis [J].

Bhaumik, Sukesh R. ;

Smith, Edwin ;

Shilatifard, Ali .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2007, 14 (11) :1008-1016

[7] Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses [J].

Cabili, Moran N. ;

Trapnell, Cole ;

Goff, Loyal ;

Koziol, Magdalena ;

Tazon-Vega, Barbara ;

Regev, Aviv ;

Rinn, John L. .

GENES & DEVELOPMENT, 2011, 25 (18) :1915-1927

[8] Antisense RNA stabilization induces transcriptional gene silencing via histone deacetylation in s.: cerevisiae [J].

Camblong, Jurgi ;

Iglesias, Nahid ;

Fickentscher, Céline ;

Dieppois, Guennaelle ;

Stutz, Françoise .

CELL, 2007, 131 (04) :706-717

[9] Trans-acting antisense RNAs mediate transcriptional gene cosuppression in S. cerevisiae [J].

Camblong, Jurgi ;

Beyrouthy, Nissrine ;

Guffanti, Elisa ;

Schlaepfer, Guillaume ;

Steinmetz, Lars M. ;

Stutz, Francoise .

GENES & DEVELOPMENT, 2009, 23 (13) :1534-1545

[10] The transcriptional landscape of the mammalian genome [J].

Carninci, P ;

Kasukawa, T ;

Katayama, S ;

Gough, J ;

Frith, MC ;

Maeda, N ;

Oyama, R ;

Ravasi, T ;

Lenhard, B ;

Wells, C ;

Kodzius, R ;

Shimokawa, K ;

Bajic, VB ;

Brenner, SE ;

Batalov, S ;

Forrest, ARR ;

Zavolan, M ;

Davis, MJ ;

Wilming, LG ;

Aidinis, V ;

Allen, JE ;

Ambesi-Impiombato, X ;

Apweiler, R ;

Aturaliya, RN ;

Bailey, TL ;

Bansal, M ;

Baxter, L ;

Beisel, KW ;

Bersano, T ;

Bono, H ;

Chalk, AM ;

Chiu, KP ;

Choudhary, V ;

Christoffels, A ;

Clutterbuck, DR ;

Crowe, ML ;

Dalla, E ;

Dalrymple, BP ;

de Bono, B ;

Della Gatta, G ;

di Bernardo, D ;

Down, T ;

Engstrom, P ;

Fagiolini, M ;

Faulkner, G ;

Fletcher, CF ;

Fukushima, T ;

Furuno, M ;

Futaki, S ;

Gariboldi, M .

SCIENCE, 2005, 309 (5740) :1559-1563

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