Recent Advances in the Synthesis of Hydantoins: The State of the Art of a Valuable Scaffold

被引：184

作者：

Konnert, Laure ^{[1
]}

Lamaty, Frederic ^{[1
]}

Martinez, Jean ^{[1
]}

Colacino, Evelina ^{[1
]}

机构：

[1] Univ Montpellier, Inst Biomol Max Mousseron, UMR CNRS 5247, ENSCM, Pl E Bataillon,Campus Triolet,Cc 1703, F-34095 Montpellier, France

来源：

CHEMICAL REVIEWS | 2017年 / 117卷 / 23期

关键词：

ONE-POT SYNTHESIS; MICROWAVE-ASSISTED SYNTHESIS; D-P-HYDROXYPHENYLGLYCINE; SOLID-PHASE SYNTHESIS; ALPHA-AMINO-ACIDS; CATALYTIC ASYMMETRIC-SYNTHESIS; DIVERSITY-ORIENTED SYNTHESIS; TETRAHYDRO-BETA-CARBOLINES; BIOLOGICAL EVALUATION; DIASTEREOSELECTIVE SYNTHESIS;

D O I：

10.1021/acs.chemrev.7b00067

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The review highlights the hydantoin syntheses presented from the point of view of the preparation methods. Novel synthetic routes to various hydantoin structures, the advances brought to the classical methods in the aim of producing more sustainable and environmentally friendly procedures for the preparation of these biomolecules, and a critical comparison of the different synthetic approaches developed in the last twelve years are also described. The review is composed of 95 schemes, 8 figures and 528 references for the last 12 years and includes the description of the hydantoin-based marketed drugs and clinical candidates.

引用

页码：13757 / 13809

页数：53

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