Adjuvants for Animal Vaccines

被引：89
作者：
Burakova, Yulia [1 ,2 ]
Madera, Rachel [1 ]
McVey, Scott [3 ]
Schlup, John R. [2 ]
Shi, Jishu [1 ]
机构：
[1] Kansas State Univ, Coll Vet Med, Dept Anat & Physiol, 228 Coles Hall 1620 Denison Ave, Manhattan, KS 66506 USA
[2] Kansas State Univ, Dept Chem Engn, Coll Engn, Durland Hall, Manhattan, KS 66506 USA
[3] ARS, USDA, Arthropod Borne Anim Dis Res Unit, Manhattan, KS USA
来源：
VIRAL IMMUNOLOGY | 2018年 / 31卷 / 01期
关键词：
adjuvants; veterinary vaccines; emulsions; Toll-like receptor agonists; saponins; cytokines; MOUTH-DISEASE VACCINE; PROTECTIVE IMMUNE-RESPONSE; CELL-MEDIATED-IMMUNITY; CALCIUM-PHOSPHATE; ALUMINUM-HYDROXIDE; SUBUNIT VACCINE; ISA; 206; CPG OLIGODEOXYNUCLEOTIDE; ANTIBODY-PRODUCTION; EMULSION VACCINES;
D O I：
10.1089/vim.2017.0049
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Vaccines are essential tools for the prevention and control of infectious diseases in animals. One of the most important steps in vaccine development is the selection of a suitable adjuvant. The focus of this review is the adjuvants used in vaccines for animals. We will discuss current commercial adjuvants and experimental formulations with attention to mineral salts, emulsions, bacterial-derived components, saponins, and several other immunoactive compounds. In addition, we will also examine the mechanisms of action for different adjuvants, examples of adjuvant combinations in one vaccine formulation, and challenges in the research and development of veterinary vaccine adjuvants.
引用
收藏
页码：11 / 22
页数：12
相关论文
共 147 条
[1]   ADJUVANTICITY OF ALUMINUM HYDROXIDE AND CALCIUM-PHOSPHATE IN DIPHTHERIA-TETANUS VACCINES .1. [J].
AGGERBECK, H ;
HERON, I .
VACCINE, 1995, 13 (14) :1360-1365
[2]   Polyphosphazene polyelectrolytes: A link between the formation of noncovalent complexes with antigenic proteins and immunostimulating activity [J].
Andrianov, AK ;
Marin, A ;
Roberts, BE .
BIOMACROMOLECULES, 2005, 6 (03) :1375-1379
[3]   Cytokines as adjuvants for avian vaccines [J].
Asif, M ;
Jenkins, KA ;
Hilton, LS ;
Kimpton, WG ;
Bean, AGD ;
Lowenthal, JW .
IMMUNOLOGY AND CELL BIOLOGY, 2004, 82 (06) :638-643
[4]   Activation of adjuvant core response genes by the novel adjuvant PCEP [J].
Awate, Sunita ;
Wilson, Heather L. ;
Lai, Ken ;
Babiuk, Lorne A. ;
Mutwiri, George .
MOLECULAR IMMUNOLOGY, 2012, 51 (3-4) :292-303
[5]   APPLICATION OF INTERFERONS IN THE CONTROL OF INFECTIOUS-DISEASES OF CATTLE [J].
BABIUK, LA ;
SORDILLO, LM ;
CAMPOS, M ;
HUGHES, HPA ;
ROSSICAMPOS, A ;
HARLAND, R .
JOURNAL OF DAIRY SCIENCE, 1991, 74 (12) :4385-4398
[6]   International bank for foot-and-mouth disease vaccine: Assessment of Montanide ISA 25 and ISA 206, two commercially available oil adjuvants [J].
Barnett, PV ;
Pullen, L ;
Williams, L ;
Doel, TR .
VACCINE, 1996, 14 (13) :1187-1198
[7]   Adjuvant formulations designed to improve swine vaccine stability: Application to PCV2 vaccines [J].
Ben Arous, J. ;
Bertrand, F. ;
Gaucheron, J. ;
Verkhovsky, O. A. ;
Kotelnikov, A. P. ;
Shemelkov, E. V. ;
Alekseev, K. P. ;
Dupuis, L. .
6TH VACCINE & ISV CONGRESS, 2013, 7 :34-39
[8]   Reduction of Newcastle disease vaccine dose using a novel adjuvant for cellular immune response in poultry [J].
Ben Arous, J. ;
Deville, S. ;
Pal, J. K. ;
Baksi, S. ;
Bertrand, F. ;
Dupuis, L. .
6TH VACCINE & ISV CONGRESS, 2013, 7 :28-33
[9]   A New Adjuvant Combined with Inactivated Influenza Enhances Specific CD8 T Cell Response in Mice and Decreases Symptoms in Swine Upon Challenge [J].
Bouguyon, Edwige ;
Goncalves, Elodie ;
Shevtsov, Alexander ;
Maisonnasse, Pauline ;
Remyga, Stepan ;
Goryushev, Oleg ;
Deville, Sebastien ;
Bertho, Nicolas ;
Ben Arous, Juliette .
VIRAL IMMUNOLOGY, 2015, 28 (09) :524-531
[10]   Vaccine delivery to animals [J].
Bowersock, TL ;
Martin, S .
ADVANCED DRUG DELIVERY REVIEWS, 1999, 38 (02) :167-194
12345678910