Estrogen regulates bcl-x expression in rat hippocampus

被引：37
|
作者：
Stoltzner, SE
Berchtold, NC
Cotman, CW
Pike, CJ
机构：
[1] Univ So Calif, Ethel Percy Andrus Gerontol Ctr, Los Angeles, CA 90089 USA
[2] Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92697 USA
来源：
NEUROREPORT | 2001年 / 12卷 / 13期
关键词：
Alzheimer's disease; apoptosis; bcl-x; estrogen; neuroprotection;
D O I：
10.1097/00001756-200109170-00009
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In this study, we examined whether experimental alterations of circulating estrogen levels are associated with changes in the expression of bcl-x, an inhibitor of apoptosis. We report that bcl-x mRNA expression in rat hippocampus significantly decreases after reduction of estrogen levels resulting from ovariectomy. Exposure of ovariectomized rats to 17 beta -estradiol for either 5 or 28 days restored bcl-x mRNA expression to levels at or above those observed in sham-ovariectomized control animals. These data demonstrate that physiological levels of estrogen regulate hippocampal expression of bct-x, an important modulator of neuronal apoptosis. Estrogen-mediated regulation of bcl-x may be relevant to the maintenance of neuronal viability and may contribute to the mechanism of estrogen neuroprotection. NeuroReport 12:2797-2800 (C) 2001 Lippincott Williams & Wilkins.
引用
收藏
页码：2797 / 2800
页数：4
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