Cytomorphometric analysis of crack cocaine effects on the oral mucosa

被引：27

作者：

Cogo Woyceichoski, Iverson Ernani ^{[1
]}

de Arruda, Elcy Pinto ^{[2
]}

Resende, Luciane Grochocki ^{[1
]}

Naval Machado, Maria Angela ^{[1
]}

Trindade Gregio, Ana Maria ^{[3
]}

Azevedo, Luciana Reis ^{[2
]}

Soares de Lima, Antonio Adilson

机构：

[1] Pontif Cathol Univ Parana, Sch Dent, Dept Oral Pathol, Curitiba, Parana, Brazil

[2] Pontif Cathol Univ Parana, Sch Dent, Dept Stomatol, Curitiba, Parana, Brazil

[3] Pontif Cathol Univ Parana, Sch Dent, Dept Pharmacol & Therapeut, Curitiba, Parana, Brazil

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY | 2008年 / 105卷 / 06期

关键词：

D O I：

10.1016/j.tripleo.2007.09.011

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objective. This study assessed the effect of smoking crack cocaine on the nuclear area (NA), the cytoplasmic area (CA), and the nucleus-to-cytoplasm area ratio (NA/CA) of oral squamous epithelial cells. Study design. Oral smears were collected from clinically normal-appearing mucosa by liquid-based exfoliative cytology of 40 individuals (20 crack users and 20 nonusers) and analyzed for quantitative techniques using an image analysis system. Results. Mean values of NA for experimental and control groups were, respectively, 49.85 mu m(2) and 62.68 mu m(2) (P < .01). CA showed the following mean values: 1820.9 mu m(2) (experimental) and 1780.8 mu m(2) (control). NA/CA for the experimental group was 0.03; the control group was 0.04 (P < .01). Conclusion. This study revealed that crack cocaine was able to induce significant changes on the oral epithelial cells. Since this illicit drug is normally used in association with other risk factors for oral cancer ( tobacco and alcohol), crack cocaine abusers should have frequent preventive oral exams.

引用

页码：745 / 749

页数：5

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