The Influence of Levetiracetam in Cognitive Performance in Healthy Individuals: Neuropsychological, Behavioral and Electrophysiological Approach

被引：33

作者：

Magalhaes, Julio Cesar ^{[1
]}

Gongora, Mariana ^{[1
]}

Vicente, Renan ^{[1
,2
]}

Bittencourt, Juliana ^{[1
,4
,7
]}

Tanaka, Guaraci ^{[1
]}

Velasques, Bruna ^{[1
,2
,4
]}

Teixeira, Silmar ^{[5
]}

Morato, Gledys ^{[5
]}

Basile, Luis F. ^{[6
]}

Arias-Carrion, Oscar ^{[8
,9
]}

Pompeu, Fernando A. M. S. ^{[2
]}

Cagy, Mauricio ^{[3
]}

Ribeiro, Pedro ^{[1
,2
,4
]}

机构：

[1] Fed Univ Rio de Janeiro IPUB UFRJ, Inst Psychiat, Brain Mapping & Sensory Motor Integrat, Rio De Janeiro, Brazil

[2] Univ Fed Rio de Janeiro, Sch Phys Educ, Biosci Dept EEFD UFRJ, Rio De Janeiro, Brazil

[3] Univ Fed Rio de Janeiro, COPPE, Biomed Engn Program, BR-21945 Rio De Janeiro, Brazil

[4] INA, Rio De Janeiro, Brazil

[5] Univ Fed Piaui, Brain Mapping & Plast Lab, Teresina, Brazil

[6] UMESP, Fac Saude, Lab Psychophysiol, Sao Paulo, Brazil

[7] Univ Veiga de Almeida, Rio De Janeiro, Brazil

[8] Hosp Gen Dr Manuel Gea Gonzalez, Movement Disorders & Transcranial Magnet Stimulat, Mexico City, DF, Mexico

[9] Hosp Gen Ajusco Medio, Dept Neurol, Mexico City, DF, Mexico

来源：

CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE | 2015年 / 13卷 / 01期

关键词：

Levetiracetam; Neuropsychological tests; Reaction time; Electroencephalography; Absolute theta; WORKING-MEMORY; RESPONSE-INHIBITION; ATTENTIONAL CONTROL; FRONTAL-CORTEX; ANTIEPILEPTIC DRUGS; ALZHEIMERS-DISEASE; EPILEPSY PATIENTS; DECISION-MAKING; OPEN-LABEL; EEG;

D O I：

10.9758/cpn.2015.13.1.83

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Objective: The present study sought to analyze the influence of Levetiracetam (LEV) in cognitive performance by identifying the changes produced by LEV in reaction time, in neuropsychological assessment of attention and memory and in absolute theta power in frontal activity. Methods: Twelve healthy subjects (5 men and 7 women; mean age, 30.08 years, standard deviation, 4.71) were recruited for this study. The neuropsychological tests: Trail Making Test (A and B), Digit Span (direct and indirect numerical orders/working memory); Stroop test (inhibitory control of attention); Tower of London (planning and decision making) and a quantitative electroencephalography were applied in 2 different days after and before the participants ingested the capsule of placebo or 500 mg LEV. Results: A two-way-ANOVA was implemented to observe the interaction between conditions (placebo or LEV 500 mg) and moments (pre- and post-ingestion of LEV or placebo). The data were analyzed by the SPSS statistical package (p<0.05). For the neuropsychological parameter, the Trail Making Test (A) was the only test that showed significant difference for condition in the task execution time (p=0.026). Regarding the reaction time in the behavioral parameter, an interaction between both factors (p=0.034) was identified through a two-way-ANOVA (condition versus moment). Electrophysiological measures showed a significant interaction for electrodes: F7, F3, and FZ. Conclusion: The findings showed that LEV promotes an important cognitive enhancement in the executive functions.

引用

页码：83 / 93

页数：11

共 80 条

[61] Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model [J].