Roles of mitochondrial DNA in dynamics of the immune response to COVID-19

被引：11

作者：

Mahmoodpoor, Ata ^{[1
]}

Sanaie, Sarvin ^{[1
]}

Ostadi, Zoherh ^{[2
]}

Eskandari, Maqsoud ^{[2
]}

Behrouzi, Nazila ^{[2
]}

Asghari, Roqayyeh ^{[2
]}

Zahirnia, Ahmad ^{[3
]}

Sohrabifar, Nasim ^{[4
]}

Kazeminasab, Somayeh ^{[3
,5
]}

机构：

[1] Tabriz Univ Med Sci, Res Ctr Integrat Med Aging, Aging Res Inst, Tabriz, Iran

[2] Tabriz Univ Med Sci, Fac Med, Dept Anesthesiol & Intens Care, Tabriz, Iran

[3] Nasle Farda Hlth Fdn, Med Genet Lab, Tabriz, Iran

[4] Shahid Beheshti Univ Med Sci, Cardiovasc Res Ctr, Tehran, Iran

[5] Tabriz Univ Med Sci, Fac Med, Dept Med Genet, Tabriz, Iran

来源：

GENE | 2022年 / 836卷

关键词：

mtDNA; ccf-mtDNA; Immune response; Inflammasome; COVID-19; SARS-CoV-2; NLRP3; INFLAMMASOME; LUNG INJURY; CGAS; SARS-COV-2; INFECTION; DISEASE; MAVS; ACTIVATION; MECHANISMS; INSIGHTS;

D O I：

10.1016/j.gene.2022.146681

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mitochondria dynamics have a pivotal role in many aspects of immune function. Viral infections affect mitochondrial dynamics and trigger the release of mitochondrial DNA (mtDNA) in host cells. Released mtDNA guides the immune response towards an inflammatory response against pathogens. In addition, circulating cell-free mtDNA (ccf-mtDNA) is considered an invaluable indicator for the prognosis and severity of infectious diseases. This study provides an overview of the role of mtDNA in the dynamics of the immune response to COVID-19. We focused on the possible roles of mtDNA in inducing the signaling pathways, and the inflammasome activation and regulation in SARS-CoV-2. Targeting mtDNA-related pathways can provide critical insights into therapeutic strategies for COVID-19.

引用

页数：7

共 99 条

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