Statistical mechanics of prion diseases -: art. no. 058101

被引：23

作者：

Slepoy, A ^{[1
]}

Singh, RRP ^{[1
]}

Pázmándi, F ^{[1
]}

Kulkarni, RV ^{[1
]}

Cox, DL ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Phys, Davis, CA 95616 USA

来源：

PHYSICAL REVIEW LETTERS | 2001年 / 87卷 / 05期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1103/PhysRevLett.87.058101

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We present a two-dimensional, lattice based., protein-level statistical mechanical model for prion diseases (e.g., mad cow disease) with concomitant prion protein misfolding and aggregation. Our studies lead us to the hypothesis that the observed broad incubation time distribution in epidemiological data reflect fluctuation dominated growth seeded by a few nanometer scale aggregates, while much narrower incubation time distributions for innoculated lab animals arise from statistical self-averaging. We model "species barriers" to prion infection and assess a related treatment protocol.

引用

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页码：58101 / 1

页数：4

相关论文

共 28 条

[1] Mapping the early steps in the pH-induced conformational conversion of the prion protein [J].

Alonso, DOV ;

DeArmond, SJ ;

Cohen, FE ;

Daggett, V .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (06) :2985-2989

[2] Transmission dynamics and epidemiology of BSE in British cattle [J].

Anderson, RM ;

Donnelly, CA ;

Ferguson, NM ;

Woolhouse, MEJ ;

Watt, CJ ;

Udy, HJ ;

MaWhinney, S ;

Dunstan, SP ;

Southwood, TRE ;

Wilesmith, JW ;

Ryan, JBM ;

Hoinville, LJ ;

Hillerton, JE ;

Austin, AR ;

Wells, GAH .

NATURE, 1996, 382 (6594) :779-788

[3] Sequential appearance and accumulation of pathognomonic markers in the central nervous system of hamsters orally infected with scrapie [J].

Beekes, M ;

Baldauf, E ;

Diringer, H .

JOURNAL OF GENERAL VIROLOGY, 1996, 77 :1925-1934

[4]

Coghlan A, 2000, NEW SCI, V168, P4

[5] A KINETIC-MODEL FOR AMYLOID FORMATION IN THE PRION DISEASES - IMPORTANCE OF SEEDING [J].

COME, JH ;

FRASER, PE ;

LANSBURY, PT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (13) :5959-5963

[6]

Demaimay R, 1998, J NEUROCHEM, V71, P2534

[7] Prionics or The kinetic basis of prion diseases [J].

Eigen, M .

BIOPHYSICAL CHEMISTRY, 1996, 63 (01) :A1-A18

[8] SELF-REPLICATION AND SCRAPIE [J].

GRIFFITH, JS .

NATURE, 1967, 215 (5105) :1043-&

[9] Prion protein interconversions and the transmissible spongiform encephalopathies [J].

Horiuchi, M ;

Caughey, B .

STRUCTURE, 1999, 7 (10) :R231-R240

[10] Interactions between heterologous forms of prion protein: Binding, inhibition of conversion, and species barriers [J].

Horiuchi, M ;

Priola, SA ;

Chabry, J ;

Caughey, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (11) :5836-5841