Correlation of Cystatin-C with Glomerular Filtration Rate by Inulin Clearance in Pregnancy

被引：24

作者：

Saxena, A. R. ^{[1
]}

Karumanchi, S. Ananth ^{[2
]}

Fan, S. -L. ^{[3
]}

Horowitz, G. L. ^{[3
]}

Hollenberg, N. K. ^{[4
]}

Graves, S. W. ^{[5
]}

Seely, E. W. ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Dept Med, Div Endocrinol Diabet & Hypertens, Boston, MA 02115 USA

[2] Beth Israel Deaconess Med Ctr, Dept Med, Div Nephrol, Boston, MA 02215 USA

[3] Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA

[4] Brigham & Womens Hosp, Dept Radiol, Physiol Res Div, Boston, MA 02115 USA

[5] Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA

来源：

HYPERTENSION IN PREGNANCY | 2012年 / 31卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Cystatin-C; Glomerular filtration rate; Inulin; Kidney function test; Pregnancy; BETA-TRACE PROTEIN; RENAL-FUNCTION; SERIAL CHANGES; CREATININE; HEMODYNAMICS; DYSFUNCTION; PREDICTION; PUERPERIUM; MARKER; URATE;

D O I：

10.3109/10641955.2010.507845

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective. To test utility of cystatin-C as a marker of glomerular filtration rate during pregnancy, we performed serial correlations with inulin clearance during pregnancy and postpartum. Methods. Twelve subjects received inulin infusions and serum cystatin-C at three time points. Pearson's correlation coefficient was calculated. Results. Cystatin-C levels ranged 0.66-1.48 mg/L during pregnancy, and 0.72-1.26 mg/L postpartum. Inulin clearance ranged 130-188 mL/min during pregnancy, and 110-167 mL/min postpartum. Cystatin-C did not correlate with inulin clearance at any time point. Conclusion. Serum cystatin-C did not correlate with inulin clearance during pregnancy or postpartum.

引用

页码：22 / 30

页数：9

共 31 条

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