A new deep convolutional neural network model for classifying breast cancer histopathological images and the hyperparameter optimisation of the proposed model

被引:45
作者
Burcak, Kadir Can [1 ]
Baykan, Omer Kaan [2 ]
Uguz, Harun [2 ]
机构
[1] Ahi Evran Univ, Comp Sci Res & Applicat Ctr, Kirsehir, Turkey
[2] Konya Tech Univ, Fac Engn & Nat Sci, Dept Comp Engn, Konya, Turkey
关键词
Deep learning; Convolutional neural network; Breast cancer; Histopathology; Image classification; MITOSIS DETECTION; CLASSIFICATION;
D O I
10.1007/s11227-020-03321-y
中图分类号
TP3 [计算技术、计算机技术];
学科分类号
0812 ;
摘要
Deep learning algorithms have yielded remarkable results in medical diagnosis and image analysis, besides their contribution to improvements in a number of fields such as drug discovery, time-series modelling and optimisation methods. With regard to the analysis of histopathologic breast cancer images, the similarity of those images and the presence of healthy and tumourous tissues in different areas complicate the detection and classification of tumours on whole slide images. An accurate diagnosis in a short time is a need for full treatment in breast cancer. A successful classification on breast cancer histopathological images will overcome the burden on the pathologist and reduce the subjectivity of diagnosis. In this study, we propose a deep convolutional neural network model. The model uses various algorithms (i.e., stochastic gradient descent, Nesterov accelerated gradient, adaptive gradient, RMSprop, AdaDelta and Adam) to compute the initial weight of the network and update the model parameters for faster backpropagation learning. In order to train the model with less hardware in a short time, we used the parallel computing architecture with Cuda-enabled graphics processing unit. The results indicate that the deep convolutional neural network model is an effective classification model with a high performance up to 99.05% accuracy value.
引用
收藏
页码:973 / 989
页数:17
相关论文
共 36 条
[1]   AggNet: Deep Learning From Crowds for Mitosis Detection in Breast Cancer Histology Images [J].
Albarqouni, Shadi ;
Baur, Christoph ;
Achilles, Felix ;
Belagiannis, Vasileios ;
Demirci, Stefanie ;
Navab, Nassir .
IEEE TRANSACTIONS ON MEDICAL IMAGING, 2016, 35 (05) :1313-1321
[2]  
[Anonymous], 2018, BERKELEY ARTIFICIAL
[3]   Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer [J].
Bejnordi, Babak Ehteshami ;
Veta, Mitko ;
van Diest, Paul Johannes ;
van Ginneken, Bram ;
Karssemeijer, Nico ;
Litjens, Geert ;
van der Laak, Jeroen A. W. M. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2017, 318 (22) :2199-2210
[4]   Computer-aided diagnosis system combining FCN and Bi-LSTM model for efficient breast cancer detection from histopathological images [J].
Budak, Umit ;
Comert, Zafer ;
Rashid, Zryan Najat ;
Sengur, Abdulkadir ;
Cibuk, Musa .
APPLIED SOFT COMPUTING, 2019, 85
[5]  
Dabeer S., 2019, INFORM MED UNLOCKED, V16, P100231, DOI [10.1016/j.imu.2019.100231, DOI 10.1016/J.IMU.2019.100231]
[6]  
Dozat T., 2016, ICLR Work
[7]   Classification of breast cancer histology images using incremental boosting convolution networks [J].
Duc My Vo ;
Ngoc-Quang Nguyen ;
Lee, Sang-Woong .
INFORMATION SCIENCES, 2019, 482 :123-138
[8]   Computer-Aided Breast Cancer Diagnosis Based on the Analysis of Cytological Images of Fine Needle Biopsies [J].
Filipczuk, Pawel ;
Fevens, Thomas ;
Krzyzak, Adam ;
Monczak, Roman .
IEEE TRANSACTIONS ON MEDICAL IMAGING, 2013, 32 (12) :2169-2178
[9]   Remote Computer-Aided Breast Cancer Detection and Diagnosis System Based on Cytological Images [J].
George, Yasmeen Mourice ;
Zayed, Hala Helmy ;
Roushdy, Mohamed Ismail ;
Elbagoury, Bassant Mohamed .
IEEE SYSTEMS JOURNAL, 2014, 8 (03) :949-964
[10]   Breast Cancer Multi-classification from Histopathological Images with Structured Deep Learning Model [J].
Han, Zhongyi ;
Wei, Benzheng ;
Zheng, Yuanjie ;
Yin, Yilong ;
Li, Kejian ;
Li, Shuo .
SCIENTIFIC REPORTS, 2017, 7