A fast and efficient one-pot microwave assisted synthesis of variously di-substituted 1,2,4-oxadiazoles

被引：23

作者：

Porcheddu, Andrea ^{[1
]}

Cadoni, Roberta ^{[1
]}

De Luca, Lidia ^{[1
]}

机构：

[1] Univ Sassari, Dipartimento Chim, I-07100 Sassari, Italy

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 21期

关键词：

SOLVENT-FREE CONDITIONS; 3-COMPONENT SYNTHESIS; SH2; INHIBITORS; DISCOVERY; OXADIAZOLES; RECEPTOR; AGONISTS; ACID; DERIVATIVES; ANTAGONISTS;

D O I：

10.1039/c1ob06055d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot two-step microwave assisted synthesis of variously disubstituted 1,2,4-oxadiazoles from carboxylic acids and amidoximes is reported. This methodology is characterized by short reaction times, is versatile, robust and high-yielding and allows for the preparation of heterocycles with a stereocenter with 100% enantiomeric purity.

引用

收藏

页码：7539 / 7546

页数：8

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