Mesoporous silica-coated gold nanorods with embedded indocyanine green for dual mode X-ray CT and NIR fluorescence imaging

被引：110

作者：

Luo, Teng ^{[1
]}

Huang, Peng ^{[2
]}

Gao, Guo ^{[2
]}

Shen, Guangxia ^{[2
]}

Fu, Shen ^{[3
]}

Cui, Daxiang ^{[2
]}

Zhou, Chuanqing ^{[1
]}

Ren, Qiushi ^{[4
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200240, Peoples R China

[2] Shanghai Jiao Tong Univ, Natl Key Lab Nano Micro Fabricat Technol, Key Lab Thin Film & Microfabricat, Minist Educ,Inst Micro Nano Sci & Technol, Shanghai 200240, Peoples R China

[3] Shanghai Jiao Tong Univ, Dept Radiat Oncol, Shanghai Peoples Hosp 5, Shanghai 200233, Peoples R China

[4] Peking Univ, Dept Biomed Engn, Coll Engn, Beijing 100871, Peoples R China

来源：

OPTICS EXPRESS | 2011年 / 19卷 / 18期

关键词：

COMPUTED-TOMOGRAPHY; CONTRAST AGENT; QUANTUM DOTS; PHOTOTHERMAL THERAPY; NANOPARTICLES; RESONANCE; DELIVERY; CANCER; NANOCOMPOSITES; STABILIZATION;

D O I：

10.1364/OE.19.017030

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Indocyanine green-loaded mesoporous silica-coated gold nanorods (ICG-loaded Au@SiO2) were prepared for the dual capability of X-ray computed tomography (CT) and fluorescence imaging. X-ray CT scanning showed that ICG-loaded Au@SiO2 could provide significant contrast enhancement; Near-infrared fluorescence generated by the nanomaterial was present up to 12 h post intratumoral injection, thus enabling ICG-loaded Au@SiO2 to be used as a promising dual mode imaging contrast agent. Multiplexed images can be more easily obtained with this novel type of multimodal nanostructure compared with traditional contrast agents. The dual mode imaging probe has great potential for use in applications such as cancer targeting, molecular imaging in combination with radiotherapy, and photothermolysis. (C) 2011 Optical Society of America

引用

页码：17030 / 17039

页数：10