Recent insights into synthetic β-carbolines with anti-cancer activities

被引：80

作者：

Kumar, Sumit ^{[1
]}

Singh, Amandeep ^{[1
]}

Kumar, Kewal ^{[2
]}

Kumar, Vipan ^{[1
]}

机构：

[1] Guru Nanak Dev Univ, Dept Chem, Amritsar 143005, Punjab, India

[2] MRSPTU, Dept Appl Chem, Coll Engn & Technol, Giani Zail Singh Campus,Dabwali Rd, Bathinda 151001, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2017年 / 142卷

关键词：

beta-Carbolines; Anti-cancer activity; Structure Activity Relationship; Synthetic strategies; POTENTIAL ANTITUMOR AGENTS; PROTEIN-KINASE INHIBITORS; DNA-BINDING ABILITY; BIOLOGICAL EVALUATION; CYTOTOXIC ACTIVITY; DERIVATIVES; DESIGN; COMPLEXES; HARMINE; CANCER;

D O I：

10.1016/j.ejmech.2017.05.059

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cancer, an uncontrolled and rapid proliferation of abnormal cells, has become one of the leading cause of death worldwide. The development of resistance among the numerous drugs in clinical use has provided strong impetus for the identification and development of novel cancer therapeutics. beta-carbolines constitute an important class of pharmacologically active scaffolds known to exert their anticancer activities via diverse mechanisms. The purpose of present review article is to update the readers on the current developments in beta-carbolines with an emphasis on synthetic strategies, structure-activity relationships, mechanism of action and in vivo studies wherever possible. (C) 2017 Elsevier Masson SAS. All rights reserved.

引用

页码：48 / 73

页数：26

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