Interactions of antifungal plant defensins with fungal membrane components

被引：158

作者：

Thevissen, K ^{[1
]}

Ferket, KKA ^{[1
]}

François, IEJA ^{[1
]}

Cammue, BPA ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Ctr Microbial & Plant Genet, B-3001 Heverlee, Belgium

来源：

PEPTIDES | 2003年 / 24卷 / 11期

关键词：

plant defensin; sphingolipid; glucosylceramide; Neurospora crassa; Saccharomyces cerevisiae; Pichia pastoris; Candida albicans; mode of action;

D O I：

10.1016/j.peptides.2003.09.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plant defensins are small, basic, cysteine-rich peptides that are generally active against a broad spectrum of fungal and yeast species at micromolar concentrations. Some of these defensins interact with fungal-specific lipid components in the plasmamembrane. Structural differences of these membrane components between fungal and plant cells probably account for the selective activity of plant defensins against fungal pathogens and their nonphytotoxic properties. This review will focus on different classes of complex lipids in fungal membranes and on the selective interaction of plant defensins with these complex lipids. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：1705 / 1712

页数：8

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