Weight loss and cystic disease progression in autosomal dominant polycystic kidney disease

被引：32

作者：

Hopp, Katharina ^{[1
,2
]}

Catenacci, Victoria A. ^{[3
]}

Dwivedi, Nidhi ^{[1
]}

Kline, Timothy L. ^{[4
,5
]}

Wang, Wei ^{[1
]}

You, Zhiying ^{[1
]}

Nguyen, Dustin T. ^{[1
]}

Bing, Kristen ^{[3
]}

Poudyal, Bhavya ^{[4
]}

Johnson, Ginger C. ^{[3
]}

Jackman, Matthew R. ^{[3
]}

Miller, Marsha ^{[3
]}

Steele, Cortney N. ^{[1
]}

Serkova, Natalie J. ^{[6
]}

MacLean, Paul S. ^{[3
]}

Nemenoff, Raphael A. ^{[1
,2
]}

Gitomer, Berenice ^{[1
]}

Chonchol, Michel ^{[1
,2
]}

Nowak, Kristen L. ^{[1
]}

机构：

[1] Univ Colorado, Div Renal Dis & Hypertens, Dept Med, Anschutz Med Campus, Aurora, CO 80045 USA

[2] Univ Colorado, Consortium Fibrosis Res & Translat, Anschutz Med Campus, Aurora, CO 80045 USA

[3] Univ Colorado, Div Endocrinol, Dept Med, Anschutz Med Campus, Aurora, CO 80045 USA

[4] Mayo Clin, Dept Radiol, Coll Med, Rochester, MN 55901 USA

[5] Mayo Clin, Div Nephrol & Hypertens, Coll Med, Rochester, MN 55901 USA

[6] Univ Colorado, Dept Radiol, Anschutz Med Campus, Aurora, CO 80045 USA

来源：

ISCIENCE | 2022年 / 25卷 / 01期

基金：

美国国家卫生研究院;

关键词：

PROGNOSTIC ENRICHMENT DESIGN; CALORIC RESTRICTION; CLINICAL-TRIALS; MOUSE MODEL; OVERWEIGHT; TOLVAPTAN; CRITERIA; OBESITY; ADULTS; VOLUME;

D O I：

10.1016/j.isci.2021.103697

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Progression of autosomal dominant polycystic kidney disease (ADPKD) is modified by metabolic defects and obesity. Indeed, reduced food intake slows cyst growth in preclinical rodent studies. Here, we demonstrate the feasibility of daily caloric restriction (DCR) and intermittent fasting (IMF) in a cohort of overweight or obese patients with ADPKD. Clinically significant weight loss occurred with both DCR and IMF; however, weight loss was greater and adherence and tolerability were better with DCR. Further, slowed kidney growth correlated with body weight and visceral adiposity loss independent of dietary regimen. Similarly, we compared the therapeutic efficacy of DCR, IMF, and time restricted feeding (TRF) using an orthologous ADPKD mouse model. Only ADPKD animals on DCR lost significant weight and showed slowed cyst growth compared to ad libitum, IMF, or TRF feeding. Collectively, this supports therapeutic feasibility of caloric restriction in ADPKD, with potential efficacy benefits driven by weight loss.

引用

页数：24

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