mRNA vaccines in the prevention and treatment of diseases

被引：31
作者：
Gu, Yangzhuo [1 ,2 ,3 ]
Duan, Jiangyao [4 ]
Yang, Na [5 ]
Yang, Yuxin [5 ]
Zhao, Xing [1 ,2 ,3 ,5 ]
机构：
[1] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu, Peoples R China
[2] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu, Peoples R China
[3] Collaborat Innovat Ctr Biotherapy, Chengdu, Peoples R China
[4] Imperial Coll London, Dept Life Sci, London, England
[5] Guizhou Med Univ, Sch Basic Med Sci, Stem Cell & Tissue Engn Res Ctr, Guiyang 550004, Guizhou, Peoples R China
来源：
MEDCOMM | 2022年 / 3卷 / 03期
关键词：
cancer; infectious diseases; lipid nanoparticles; mRNA delivery; mRNA vaccine; DENDRITIC CELLS; LIPID NANOPARTICLES; IMMUNE-RESPONSES; SIPULEUCEL-T; PHASE IB; TRANSLATIONAL CONTROL; ANTITUMOR IMMUNITY; ALLERGIC REACTIONS; VACCINATION TRIAL; ADVANCED MELANOMA;
D O I：
10.1002/mco2.167
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Messenger ribonucleic acid (mRNA) vaccines made their successful public debut in the effort against the COVID-19 outbreak starting in late 2019, although the history of mRNA vaccines can be traced back decades. This review provides an overview to discuss the historical course and present situation of mRNA vaccine development in addition to some basic concepts that underly mRNA vaccines. We discuss the general preparation and manufacturing of mRNA vaccines and also discuss the scientific advances in the in vivo delivery system and evaluate popular approaches (i.e., lipid nanoparticle and protamine) in detail. Next, we highlight the clinical value of mRNA vaccines as potent candidates for therapeutic treatment and discuss clinical progress in the treatment of cancer and coronavirus disease 2019. Data suggest that mRNA vaccines, with several prominent advantages, have achieved encouraging results and increasing attention due to tremendous potential in disease management. Finally, we suggest some potential directions worthy of further investigation and optimization. In addition to basic research, studies that help to facilitate storage and transportation will be indispensable for practical applications.
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页数：31
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