Personalization of Repetitive Transcranial Magnetic Stimulation for the Treatment of Chronic Subjective Tinnitus

被引:5
|
作者
Schoisswohl, Stefan [1 ,2 ]
Langguth, Berthold [1 ]
Hebel, Tobias [1 ]
Vielsmeier, Veronika [2 ]
Abdelnaim, Mohamed A. [1 ]
Schecklmann, Martin [1 ]
机构
[1] Univ Regensburg, Dept Psychiat & Psychotherapy, D-93053 Regensburg, Germany
[2] Bundeswehr Univ Munich, Dept Psychol, D-85577 Neubiberg, Germany
基金
欧盟地平线“2020”;
关键词
repetitive transcranial magnetic stimulation; tinnitus; neuronavigation; rTMS personalization; neuromodulation; MOTOR CORTEX EXCITABILITY; HANDICAP INVENTORY; RTMS; INDEX; TMS; METAANALYSIS; DEPRESSION; SESSIONS; PATIENT;
D O I
10.3390/brainsci12020203
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Personalization of repetitive transcranial magnetic stimulation (rTMS) for tinnitus might be capable to overcome the heterogeneity of treatment responses. The assessment of loudness changes after short rTMS protocols in test sessions has been proposed as a strategy to identify the best protocol for the daily treatment application. However, the therapeutic advantages of this approach are currently not clear. The present study was designed to further investigate the feasibility and clinical efficacy of personalized rTMS as compared to a standardized rTMS protocol used for tinnitus. Methods: RTMS personalization was conducted via test sessions and reliable, sham-superior responses respectively short-term reductions in tinnitus loudness following active rTMS protocols (1, 10, 20 Hz, each 200 pulses) applied over the left and right temporal cortex. Twenty pulses at a frequency of 0.1 Hz served as a control condition (sham). In case of a response, patients were randomly allocated to ten treatment sessions of either personalized rTMS (2000 pulses with the site and frequency producing the most pronounced loudness reduction during test sessions) or standard rTMS (1 Hz, 2000 pulses left temporal cortex). Those participants who did not show a response during the test sessions received the standard protocol as well. Results: The study was terminated prematurely after 22 patients (instead of 50 planned) as the number of test session responders was much lower than expected (27% instead of 50%). Statistical evaluation of changes in metric tinnitus variables and treatment responses indicated only numerical, but not statistical superiority for personalized rTMS compared to standard treatment. Conclusions: The current stage of investigation does not allow for a clear conclusion about the therapeutic advantages of personalized rTMS for tinnitus based on test session responses. The feasibility of this approach is primarily limited by the low test session response rate.
引用
收藏
页数:17
相关论文
共 50 条
  • [1] Repetitive transcranial magnetic stimulation and chronic subjective tinnitus
    Dvorakova, J.
    Anders, M.
    Paclt, I.
    Raboch, J.
    Holcat, M.
    Rathova, L.
    Langguth, B.
    CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE, 2007, 70 (04) : 371 - 374
  • [2] Repetitive transcranial magnetic stimulation (rTMS) for treatment of chronic tinnitus
    Minami, Shujiro B.
    Shinden, Seiichi
    Okamoto, Yasuhide
    Watada, Yukiko
    Watabe, Takahisa
    Oishi, Naoki
    Kanzaki, Sho
    Saito, Hideyuki
    Inoue, Yasuhiro
    Ogawa, Kaoru
    AURIS NASUS LARYNX, 2011, 38 (03) : 301 - 306
  • [3] Individualized Repetitive Transcranial Magnetic Stimulation Treatment in Chronic Tinnitus?
    Kreuzer, Peter M.
    Poeppl, Timm B.
    Rupprecht, Rainer
    Vielsmeier, Veronika
    Lehner, Astrid
    Langguth, Berthold
    Schecklmann, Martin
    FRONTIERS IN NEUROLOGY, 2017, 8
  • [4] Repetitive transcranial magnetic stimulation and chronic tinnitus
    Langguth, Berthold
    Hajak, Goeran
    Kleinjung, Tobias
    Pridmore, Saxby
    Sand, Philipp
    Eichhammer, Peter
    ACTA OTO-LARYNGOLOGICA, 2006, 126 : 102 - 105
  • [5] Treatment of chronic tinnitus with low frequency repetitive transcranial magnetic stimulation
    Langguth, B.
    Landgrebe, M.
    Sand, P. G.
    Kleinjung, T.
    Hajak, G.
    Eichhammer, P.
    NERVENHEILKUNDE, 2006, 25 (08) : 649 - 652
  • [6] Treatment of chronic tinnitus with neuronavigated repetitive Transcranial Magnetic Stimulation (rTMS)
    Kleinjung, T.
    Steffens, T.
    Langguth, B.
    Eichhammer, R.
    Marienhagen, J.
    Hajak, G.
    Strutz, J.
    HNO, 2006, 54 (06) : 439 - 444
  • [7] Repetitive Transcranial Magnetic Stimulation as a Treatment for Chronic Tinnitus: A Critical Review
    Theodoroff, Sarah M.
    Folmer, Robert L.
    OTOLOGY & NEUROTOLOGY, 2013, 34 (02) : 199 - 208
  • [8] Repetitive Transcranial Magnetic Stimulation Treatment for Chronic Tinnitus A Randomized Clinical Trial
    Folmer, Robert L.
    Theodoroff, Sarah M.
    Casiana, Linda
    Shi, Yongbing
    Griest, Susan
    Vachhani, Jay
    JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY, 2015, 141 (08) : 716 - 722
  • [9] Repetitive transcranial magnetic stimulation for tinnitus
    Meng, Zhaoli
    Liu, Shixi
    Zheng, Yun
    Phillips, John S.
    COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2011, (10):
  • [10] Repetitive Transcranial Magnetic Stimulation for Tinnitus
    Folmer, Robert L.
    ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 2011, 137 (07) : 730 - 730