Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association For European Cardiovascular Pathology: II. Noninflammatory degenerative diseases - nomenclature and diagnostic criteria

被引：209

作者：

Halushka, Marc K. ^{[1
]}

Angelini, Annalisa ^{[2
]}

Bartoloni, Giovanni ^{[3
]}

Basso, Cristina ^{[2
]}

Batoroeva, Lubov ^{[4
]}

Bruneval, Patrick ^{[5
]}

Buja, L. Maximilian ^{[6
]}

Butany, Jagdish ^{[7
]}

d'Amati, Giulia ^{[8
]}

Fallon, John T. ^{[9
]}

Gallagher, Patrick J. ^{[10
]}

Gittenberger-de Groot, Adriana C. ^{[11
]}

Gouveia, Rosa H. ^{[12
]}

Kholova, Ivana ^{[13
]}

Kelly, Karen L. ^{[14
]}

Leone, Ornella ^{[15
]}

Litovsky, Silvio H. ^{[16
]}

Maleszewski, Joseph J. ^{[17
]}

Miller, Dylan V. ^{[18
]}

Mitchell, Richard N. ^{[19
]}

Preston, Stephen D. ^{[20
]}

Pucci, Angela ^{[21
]}

Radio, Stanley J. ^{[22
]}

Rodriguez, E. Rene ^{[23
]}

Sheppard, Mary N. ^{[24
]}

Stone, James R. ^{[25
]}

Suvarna, S. Kim ^{[26
]}

Tan, Carmela D. ^{[23
]}

Thiene, Gaetano ^{[2
]}

Veinot, John P. ^{[27
]}

van der Wal, Allard C. ^{[28
]}

机构：

[1] Johns Hopkins Univ, Baltimore, MD 21205 USA

[2] Univ Padua, Padua, Italy

[3] Univ Catania, Catania, Italy

[4] Russian Acad Med Sci, Irkutsk, Russia

[5] Paris Descartes Univ, Paris, France

[6] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA

[7] Toronto Gen Hosp, Toronto, ON, Canada

[8] Univ Roma La Sapienza, Piazzale Aldo Moro 5, I-00185 Rome, Italy

[9] New York Med Coll, Valhalla, NY 10595 USA

[10] Southampton Univ Hosp, Southampton, Hants, England

[11] Leiden Univ, Leiden, Netherlands

[12] Hosp Santa Cruz, Carnaxide, Portugal

[13] Fimlab Labs, Dept Pathol, Tampere, Finland

[14] E Carolina Univ, Greenville, NC USA

[15] Univ Bologna, St Orsola Malpighi Hosp, Bologna, Italy

[16] Univ Alabama Birmingham, Birmingham, AL USA

[17] Mayo Clin, Rochester, MN USA

[18] Univ Utah, Salt Lake City, UT USA

[19] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

[20] Papworth Hosp, Papworth Everard, Cambs, England

[21] Pisa Univ Hosp, Pisa, Italy

[22] Univ Nebraska, Lincoln, NE USA

[23] Cleveland Clin, Cleveland, OH 44106 USA

[24] Univ London, St Georges Med Sch, London, England

[25] Massachusetts Gen Hosp, Boston, MA 02114 USA

[26] Sheffield Teaching Hosp, Sheffield, S Yorkshire, England

[27] Univ Ottawa, Ottawa, ON, Canada

[28] Univ Amsterdam, NL-1105 AZ Amsterdam, Netherlands

来源：

CARDIOVASCULAR PATHOLOGY | 2016年 / 25卷 / 03期

关键词：

Aorta; Histopathology; Marfan syndrome; Loeys-Dietz syndrome; Bicuspid aortic valve; Medial degeneration; Cystic medial degeneration; Aneurysm; Dissection; Lamellar unit; Consensus document; Noninflammatory; Degenerative; RISK-FACTORS; ASCENDING AORTA; LAMELLAR UNIT; ANEURYSM; DISSECTION; PATHOGENESIS; ARTERIAL; COCAINE; WALL; AGE;

D O I：

10.1016/j.carpath.2016.03.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Surgical aortic specimens are usually examined in Pathology Departments as a result of treatment of aneurysms or dissections. A number of diseases, genetic syndromes (Marfan syndrome, Loeys-Dietz syndrome, etc.), and vasculopathic aging processes involved in vascular injury can cause both distinct and nonspecific histopathologic changes with degeneration of the media as a common denominator. Terminology for these changes has varied over time leading to confusion and inconsistencies. This consensus document has established a revised, unified nomenclature for the variety of noninflammatory degenerative aortic histopathologies seen in such specimens. Older terms such as cystic medial necrosis and medionecrosis are replaced by more technically accurate terms such as mucoid extracellular matrix accumulation (MEMA), elastic fiber fragmentation and/or loss, and smooth muscle cell nuclei loss. A straightforward system of grading is presented to gauge the extent of medial degeneration and synoptic reporting tables are provided. Herein we present a standardized nomenclature that is accessible to general pathologists and useful for future publications describing these entities. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：247 / 257

页数：11

共 31 条

[1] Effect of chronic cocaine abuse on the elastic properties of aorta [J].