Antimicrobial activity of rationally designed amino terminal modified peptides

被引：61
作者：
Bisht, Gopal Singh
Rawat, Diwan S.
Kumar, Anil
Kumar, Rita
Pasha, Santosh
机构：
[1] Inst Genom & Integrat Biol, Peptide Res Lab, Delhi 110007, India
[2] Univ Delhi, Dept Chem, Delhi 110007, India
[3] Inst Genom & Integrat Biol, Environm Biotechnol Div, Delhi 110007, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 15期
关键词：
cationic antimicrobial peptides; antimicrobial activity; cinnamic acid; hemolytic activity; modified peptides;
D O I：
10.1016/j.bmcl.2007.05.015
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Series of short amino terminal modified cationic peptides were designed and synthesized. All of the synthesized compounds were tested against gram-positive as well as gram-negative bacterial strain. Some of the compounds exhibit potent antibacterial activity and no hemolytic activity even at high dose level (1000 mu g/mL) in mammalian erythrocytes was observed. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4343 / 4346
页数：4
相关论文
共 50 条
[41]   Antimicrobial activity of designed undoped and doped MicNo-ZnO particles [J].
Demirel, Rasime ;
Suvaci, Ender ;
Sahin, Ismail ;
Dag, Sevinc ;
Kilic, Volkan .
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2018, 47 :309-321
[42]   Antimicrobial Activity of Amino-Derivatized Cationic Polysaccharides [J].
Patel, Sanjay K. S. ;
Kim, Jung-Hoe ;
Kalia, Vipin C. ;
Lee, Jung-Kul .
INDIAN JOURNAL OF MICROBIOLOGY, 2019, 59 (01) :96-99
[43]   Antimicrobial activity of pentaamminecobalt(III) complexes of α-amino acids [J].
Ansari, A. Thaminum ;
Subramani, K. .
ASIAN JOURNAL OF CHEMISTRY, 2008, 20 (06) :4425-4428
[44]   Antimicrobial Activity of Amino-Derivatized Cationic Polysaccharides [J].
Sanjay K. S. Patel ;
Jung-Hoe Kim ;
Vipin C. Kalia ;
Jung-Kul Lee .
Indian Journal of Microbiology, 2019, 59 :96-99
[45]   Synthetic Antimicrobial Peptides: III—Effect of Cationic Groups of Lysine, Arginine, and Histidine on Antimicrobial Activity of Peptides with a Linear Type of Amphipathicity [J].
N. V. Amirkhanov ;
A. V. Bardasheva ;
N. V. Tikunova ;
D. V. Pyshnyi .
Russian Journal of Bioorganic Chemistry, 2021, 47 :681-690
[46]   Effect of N-terminal modification on the antimicrobial activity of nisin [J].
Yu, Xuejian ;
Lu, Naiyan ;
Wang, Jiyue ;
Chen, Zhe ;
Chen, Chen ;
Mac Regenstein, Joe ;
Zhou, Peng .
FOOD CONTROL, 2020, 114
[47]   Cecropin A magainin 2 hybrid peptides having potent antimicrobial activity with low hemolytic effect [J].
Shin, SY ;
Kang, JH ;
Lee, MK ;
Kim, SY ;
Kim, YM ;
Hahm, KS .
BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, 1998, 44 (06) :1119-1126
[48]   Antimicrobial peptides from the Asian harvester ants of the genus Monomorium: In vitro screening for antimicrobial activity [J].
Bhagavathula, Naga Chaitanya ;
Meedidoddi, Venkateshwarlu ;
Chandrashekara, Krishnappa ;
Kesavakurup, Santosh Kumar .
INDIAN JOURNAL OF BIOTECHNOLOGY, 2017, 16 (01) :50-55
[49]   Synthetic Antimicrobial Peptides: III-Effect of Cationic Groups of Lysine, Arginine, and Histidine on Antimicrobial Activity of Peptides with a Linear Type of Amphipathicity [J].
Amirkhanov, N., V ;
Bardasheva, A., V ;
Tikunova, N., V ;
Pyshnyi, D., V .
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2021, 47 (03) :681-690
[50]   Synthetic Antimicrobial Peptides. II. Antimicrobial and Hemolytic Activity of Cationic Peptides Containing Cysteine Residues with Free Sulfhydryl Groups [J].
Amirkhanov, N., V ;
Tikunova, N., V ;
Pyshnyi, D., V .
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2019, 45 (06) :833-841
12345