Antimicrobial activity of rationally designed amino terminal modified peptides

被引：61

作者：

Bisht, Gopal Singh

Rawat, Diwan S.

Kumar, Anil

Kumar, Rita

Pasha, Santosh

机构：

[1] Inst Genom & Integrat Biol, Peptide Res Lab, Delhi 110007, India

[2] Univ Delhi, Dept Chem, Delhi 110007, India

[3] Inst Genom & Integrat Biol, Environm Biotechnol Div, Delhi 110007, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 15期

关键词：

cationic antimicrobial peptides; antimicrobial activity; cinnamic acid; hemolytic activity; modified peptides;

D O I：

10.1016/j.bmcl.2007.05.015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Series of short amino terminal modified cationic peptides were designed and synthesized. All of the synthesized compounds were tested against gram-positive as well as gram-negative bacterial strain. Some of the compounds exhibit potent antibacterial activity and no hemolytic activity even at high dose level (1000 mu g/mL) in mammalian erythrocytes was observed. (c) 2007 Elsevier Ltd. All rights reserved.

引用

收藏

页码：4343 / 4346

页数：4

相关论文

共 50 条

[21] Amyloid peptides with antimicrobial and/or microbial agglutination activity [J].

Dongru Chen ;

Xiangqi Liu ;

Yucong Chen ;

Huancai Lin .

Applied Microbiology and Biotechnology, 2022, 106 :7711-7720

[22] Amyloid peptides with antimicrobial and/or microbial agglutination activity [J].

Chen, Dongru ;

Liu, Xiangqi ;

Chen, Yucong ;

Lin, Huancai .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2022, 106 (23) :7711-7720

[23] DBAASP: database of antimicrobial activity and structure of peptides [J].

Gogoladze, Giorgi ;

Grigolava, Maia ;

Vishnepolsky, Boris ;

Chubinidze, Mindia ;

Duroux, Patrice ;

Lefranc, Marie-Paule ;

Pirtskhalava, Malak .

FEMS MICROBIOLOGY LETTERS, 2014, 357 (01) :63-68

[24] Antimicrobial peptides: A review of how peptide structure impacts antimicrobial activity [J].

Soares, JW ;

Mello, CM .

MONITORING FOOD SAFETY, AGRICULTURE, AND PLANT HEALTH, 2004, 5271 :20-27

[25] Antibiotic activity of reversed peptides of α-helical antimicrobial peptide, P18 [J].

Lee, SH ;

Lee, DG ;

Yang, ST ;

Kim, V ;

Kim, JI ;

Hahm, KS ;

Shin, SY .

PROTEIN AND PEPTIDE LETTERS, 2002, 9 (05) :395-402

[26] Enhancing antimicrobial activity of mastoparan-B by amino acid substitutions [J].

Yang, Mars J. ;

Lin, Wen-Yuh ;

Lin, Chun-Hsien ;

Shyu, Ching-Lin ;

Hou, Roger F. ;

Tu, Wu-Chun .

JOURNAL OF ASIA-PACIFIC ENTOMOLOGY, 2013, 16 (04) :349-355

[27] Antimicrobial activity of endogenous peptides of the moss Physcomitrella patens [J].

Khazigaleeva, R. A. ;

Vinogradova, S. V. ;

Petrova, V. L. ;

Fesenko, I. A. ;

Arapidi, G. P. ;

Kamionskaya, A. M. ;

Govorun, V. M. ;

Ivanov, V. T. .

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2017, 43 (03) :248-254

[28] Antimicrobial activity of endogenous peptides of the moss Physcomitrella patens [J].

R. A. Khazigaleeva ;

S. V. Vinogradova ;

V. L. Petrova ;

I. A. Fesenko ;

G. P. Arapidi ;

A. M. Kamionskaya ;

V. M. Govorun ;

V. T. Ivanov .

Russian Journal of Bioorganic Chemistry, 2017, 43 :248-254

[29] Effects of Hydrophobicity on the Antifungal Activity of α-Helical Antimicrobial Peptides [J].

Jiang, Ziqing ;

Kullberg, Bart Jan ;

van der Lee, Hein ;

Vasil, Adriana I. ;

Hale, John D. ;

Mant, Colin T. ;

Hancock, Robert E. W. ;

Vasil, Michael L. ;

Netea, Mihai G. ;

Hodges, Robert S. .

CHEMICAL BIOLOGY & DRUG DESIGN, 2008, 72 (06) :483-495

[30] Spectroscopic study of antimicrobial peptides: Structure and functional activity [J].

Skvortsova, Polina ;

Valiullina, Yuliya ;

Baranova, Natalia ;

Faizullin, Dzhigangir ;

Zuev, Yuriy ;

Ermakova, Elena .

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2022, 264

← 1 2 3 4 5 →