Antimicrobial activity of rationally designed amino terminal modified peptides

被引：61
|
作者：
Bisht, Gopal Singh
Rawat, Diwan S.
Kumar, Anil
Kumar, Rita
Pasha, Santosh
机构：
[1] Inst Genom & Integrat Biol, Peptide Res Lab, Delhi 110007, India
[2] Univ Delhi, Dept Chem, Delhi 110007, India
[3] Inst Genom & Integrat Biol, Environm Biotechnol Div, Delhi 110007, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 15期
关键词：
cationic antimicrobial peptides; antimicrobial activity; cinnamic acid; hemolytic activity; modified peptides;
D O I：
10.1016/j.bmcl.2007.05.015
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Series of short amino terminal modified cationic peptides were designed and synthesized. All of the synthesized compounds were tested against gram-positive as well as gram-negative bacterial strain. Some of the compounds exhibit potent antibacterial activity and no hemolytic activity even at high dose level (1000 mu g/mL) in mammalian erythrocytes was observed. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4343 / 4346
页数：4
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