Antimicrobial activity of rationally designed amino terminal modified peptides

被引：61

作者：

Bisht, Gopal Singh

Rawat, Diwan S.

Kumar, Anil

Kumar, Rita

Pasha, Santosh

机构：

[1] Inst Genom & Integrat Biol, Peptide Res Lab, Delhi 110007, India

[2] Univ Delhi, Dept Chem, Delhi 110007, India

[3] Inst Genom & Integrat Biol, Environm Biotechnol Div, Delhi 110007, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 15期

关键词：

cationic antimicrobial peptides; antimicrobial activity; cinnamic acid; hemolytic activity; modified peptides;

D O I：

10.1016/j.bmcl.2007.05.015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Series of short amino terminal modified cationic peptides were designed and synthesized. All of the synthesized compounds were tested against gram-positive as well as gram-negative bacterial strain. Some of the compounds exhibit potent antibacterial activity and no hemolytic activity even at high dose level (1000 mu g/mL) in mammalian erythrocytes was observed. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：4343 / 4346

页数：4

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